SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+

Stable Identifier
R-HSA-2424243
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, binds Collagen type I, hydroxyapatite and Ca2+, suggesting a role in the mineralization of bone and cartilage (Termine et al. 1981). It is expressed by osteoblasts, odontoblasts, and many other cell types (Romanowski et al. 1990, Mundlos et al. 1992, Papagerakis et al. 2002). SPARC expression has been used to follow the progression of osteoblast cytodifferentiation.

Literature References
PubMed ID Title Journal Year
2364322 Immunoelectron microscopy of osteonectin and type I collagen in osteoblasts and bone matrix

Romanowski, R, Jundt, G, Termine, JD, von der Mark, K, Schulz, A

Calcif. Tissue Int. 1990
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