CD209 binds ICAM3

Stable Identifier
R-HSA-5621615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
DC-SIGN binds ICAM3
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Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. CD209 binds the intracellular adhesion molecule 3 (ICAM3) with very high affinity. CD209 interacts primarily with the immunoglobulin (Ig)-like second domain of ICAM2 and ICAM3. CD209-ICAM3 interaction mediates clustering of DCs with naive T cells forming a DC-T cell synapse (Geijtenbeek et al. 2000). CD209 binding to ICAM3 is calcium dependent, and CD209 CRD (carbohydrate recognition domain) binds two Ca2+ ions, one essential for tertiary structure and the other for coordinating ligand binding (Feinberg et al. 2001, Svajger et al. 2010).

Literature References
PubMed ID Title Journal Year
10721994 Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

Geijtenbeek, TB, Torensma, R, van Vliet, SJ, van Duijnhoven, GC, Adema, GJ, van Kooyk, Y, Figdor, CG

Cell 2000
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