Influx of extracellular calcium

Stable Identifier
R-HSA-8863009
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region
ReviewStatus
5/5
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Influx of extracellular calcium
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Beta amyloid increases influx of extracellular calcium (Ca2+) through the plasma membrane, thus increasing the cytosolic Ca2+ concentration. The mechanism has not been completely elucidated (Lee et al. 2000, Abramov et al. 2004).

Literature References
PubMed ID Title Journal Year
15590058 Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

Canevari, L, Abramov, AY, Duchen, MR

Biochim. Biophys. Acta 2004
10830966 Neurotoxicity induces cleavage of p35 to p25 by calpain

Peng, J, Kwon, YT, Friedlander, RM, Lee, MS, Li, M, Tsai, LH

Nature 2000
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
APP(672-713) [extracellular region] (Homo sapiens)
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-03-03)
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