Reactome | Ca2+ influx into the post-synaptic cell

Ca2+ influx into the post-synaptic cell

Stable Identifier

R-HSA-432164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

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NMDA receptors are activated upon binding of two ligands, glutamate and glycine or D-serine. The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse (Cairns et al. 2003, reviewed by Luscher and Malenka 2012 and Sanz-Clemente et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
12815021	Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle Cairns, BE, Svensson, P, Wang, K, Hupfeld, S, Graven-Nielsen, T, Sessle, BJ, Berde, CB, Arendt-Nielsen, L	J Neurophysiol	2003