Ca2+ influx into the post-synaptic cell

Stable Identifier
R-HSA-432164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NMDA receptors are activated upon binding of two ligands, glutamate and glycine or D-serine. The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse (Cairns et al. 2003, reviewed by Luscher and Malenka 2012 and Sanz-Clemente et al. 2013).

Literature References
PubMed ID Title Journal Year
12815021 Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle

Cairns, BE, Svensson, P, Wang, K, Hupfeld, S, Graven-Nielsen, T, Sessle, BJ, Berde, CB, Arendt-Nielsen, L

J Neurophysiol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
excitatory extracellular ligand-gated ion channel activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created