NMDA receptors are activated upon binding of two ligands, glutamate and glycine or D-serine. The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse (Cairns et al. 2003, reviewed by Luscher and Malenka 2012 and Sanz-Clemente et al. 2013).
Berde, CB, Svensson, P, Cairns, BE, Sessle, BJ, Arendt-Nielsen, L, Wang, K, Hupfeld, S, Graven-Nielsen, T
excitatory extracellular ligand-gated ion channel activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane]
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