Reactome | S100A8:S100A9:Ca2+ [extracellular region]

Stable Identifier

R-HSA-8944198

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Synonyms

calprotectin heterotetramer

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Literature References

PubMed ID	Title	Journal	Year
10976885	Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysis Strupat, K, Rogniaux, H, Vogl, T, Roth, J, Van Dorsselaer, A	J. Am. Soc. Mass Spectrom.	2000
16690079	Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity Roth, J, Strupat, K, Sorg, C, Vogl, T, Reichelt, R, Leukert, N	J. Mol. Biol.	2006
25597447	Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis Nolan, EM, Brophy, MB, Drennan, CL, Gagnon, DM, Britt, RD, Stich, TA, Bowman, SE	J. Am. Chem. Soc.	2015
17553524	The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins Skerra, A, Brueckner, F, Korndörfer, IP	J. Mol. Biol.	2007

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