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activated thrombin (factor IIa) [extracellular region]
Stable Identifier
R-BTA-156786
Type
Complex
Species
Bos taurus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
Common Pathway of Fibrin Clot Formation (Bos taurus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
factor V -> factor Va + factor V activation peptide (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Thrombin binding to GP1b:IX:V (Bos taurus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Complement cascade (Bos taurus)
Regulation of Complement cascade (Bos taurus)
Thrombin, ELANE cleave C5 (Bos taurus)
Activated thrombin, (ELANE) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Peptide ligand-binding receptors (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
Ca2+ [extracellular region]
F2 [extracellular region]
(Bos taurus)
F2 [extracellular region]
(Bos taurus)
Participates
as an input of
Thrombin binding to GP1b:IX:V (Bos taurus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
as a component of
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
as an output of
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
as a member of
Activated thrombin, (ELANE) [extracellular region] (Bos taurus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
Inferred From
activated thrombin (factor IIa) [extracellular region]
(Homo sapiens)
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