ATP2B1-4 transport cytosolic Ca2+ to extracellular region

Stable Identifier
R-HSA-418309
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PMCA extrusion of Ca2+
ReviewStatus
5/5
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ATP2B1-4 transport cytosolic Ca2+ to extracellular region
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The plasma membrane Ca-ATPases 1-4 (ATP2B1-4, PMCAs) are P-type Ca2+-ATPases regulated by calmodulin. The PMCA also counter-transports a proton. PMCA is important for Ca2+ homeostasis and function.
Literature References
PubMed ID Title Journal Year
5961668 ATP-dependent Ca++-extrusion from human red cells

Schatzmann, HJ

Experientia 1966
2844759 Complete primary structure of a human plasma membrane Ca2+ pump

Verma, AK, Filoteo, AG, Stanford, DR, Wieben, ED, Penniston, JT, Strehler, EE, Fischer, R, Heim, R, Vogel, G, Mathews, S

J Biol Chem 1988
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Catalyst Activity

P-type calcium transporter activity of ATP2B1-4 [plasma membrane]

Physical Entity
ATP2B1-4 [plasma membrane] (Homo sapiens)
Activity
P-type calcium transporter activity (GO:0005388)
Orthologous Events
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Saccharomyces cerevisiae)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)
Cross References
RHEA
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-04-21)
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