Reactome | TRPV1 transports Ca2+ from extracellular region to cytosol

TRPV1 transports Ca2+ from extracellular region to cytosol

Stable Identifier

R-HSA-9701141

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

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TRPV1 transports Ca2+ from extracellular region to cytosol

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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in the detection of noxious chemical and thermal stimuli. It is involved in the mediation of inflammatory pain and hyperalgesia (Hayes et al. 2000, Cortright et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11243859	The tissue distribution and functional characterization of human VR1 Cortright, DN, Crandall, M, Sanchez, JF, Zou, T, Krause, JE, White, G	Biochem. Biophys. Res. Commun.	2001
20025796	Structure-functional intimacies of transient receptor potential channels Latorre, R, Zaelzer, C, Brauchi, S	Q. Rev. Biophys.	2009
11050376	Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 Hayes, P, Meadows, HJ, Gunthorpe, MJ, Harries, MH, Duckworth, DM, Cairns, W, Harrison, DC, Clarke, CE, Ellington, K, Prinjha, RK, Barton, AJ, Medhurst, AD, Smith, GD, Topp, S, Murdock, P, Sanger, GJ, Terrett, J, Jenkins, O, Benham, CD, Randall, AD, Gloger, IS, Davis, JB	Pain	2000
20716668	International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family Wu, LJ, Sweet, TB, Clapham, DE	Pharmacol. Rev.	2010