Ca2+ influx through voltage gated Ca2+ channels

Stable Identifier
R-HSA-210420
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ca2+ influx from the extracellular space into the presynaptic neuron through the Voltage Gated Ca2+ Channels (VGCC), is dependant on the arrival of an action potential at the synaptic bulb. The vesicle fusion and subsequent release of glutamate into the synapse is triggered by this influx of Ca2+. The VGCCs involved here could be of the N, P/Q or R type.

Hyperpolarization of the cell membrane due to KIR3 potassium channel activity inhibits this influx of Ca2+.

Literature References
PubMed ID Title Journal Year
8825650 Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits

Diriong, S, Lory, P, Williams, ME, Ellis, SB, Harpold, MM, Taviaux, S

Genomics 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium channel activity of Voltage Gated Ca2+ Channel [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created