CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9663785
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol
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In response to binding acetylcholine (AcCho), the CHRNA9:CHRNA10 receptor transports calcium ions from the extracellular region to the cytosol (inferred from rat homologs). CHRNA9:CHRNA10 receptors are clustered at cholinergic synapses in the basal region of outer hair cells (OHCs) (inferred from rat homologs). The influx of calcium causes opening of SK2 channels (KCNN2) and BK channels (KCNMA1:KCNMB1), efflux of potassium ions, hyperpolarization, and inhibition of contraction of the OHCs.
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Output
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as an event of
Catalyst Activity

calcium channel activity of CHRNA9:CHRNA10:AcCho [plasma membrane]

Physical Entity
CHRNA9:CHRNA10:AcCho [plasma membrane] (Homo sapiens)
Activity
calcium channel activity (GO:0005262)
Inferred From
Chrna9:Chrna10:AcCho transports calcium ions from the extracellular region to the cytosol (Rattus norvegicus)
Cross References
Rhea
Authored
May, B  (2019-10-08)
Reviewed
Dallos, P  (2020-09-14)
Furness, DN  (2020-09-14)
Created
May, B  (2019-10-12)
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