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activated thrombin (factor IIa) [extracellular region]
Stable Identifier
R-GGA-156786
Type
Complex
Species
Gallus gallus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Formation of Fibrin Clot (Clotting Cascade) (Gallus gallus)
Common Pathway of Fibrin Clot Formation (Gallus gallus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
factor V -> factor Va + factor V activation peptide (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Intrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Thrombin binding to GP1b:IX:V (Gallus gallus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Thrombin signalling through proteinase activated receptors (PARs) (Gallus gallus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Complement cascade (Gallus gallus)
Regulation of Complement cascade (Gallus gallus)
Thrombin, ELANE cleave C5 (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (q) signalling events (Gallus gallus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Peptide ligand-binding receptors (Gallus gallus)
Proteinase-activated receptors can bind thrombin (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
Ca2+ [extracellular region]
thrombin heavy chain [extracellular region]
(Gallus gallus)
thrombin light chain [extracellular region]
(Gallus gallus)
Participates
as an input of
Thrombin binding to GP1b:IX:V (Gallus gallus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)
Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)
Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)
Proteinase-activated receptors can bind thrombin (Gallus gallus)
as a component of
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
as an output of
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
Inferred From
Activated thrombin, (ELANE) [extracellular region]
(Homo sapiens)
activated thrombin (factor IIa) [extracellular region]
(Homo sapiens)
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