TRPC1 translocates calcium from the extracellular region to the cytosol

Stable Identifier
R-HSA-2089943
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Calcium Influx via TRPC1
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRPC1 forms a channel that transports Ca2+ across the plasma membrane. TRPC1 is gated by STIM1 (Ong et al. 2007).

Literature References
PubMed ID Title Journal Year
17486119 STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

Yuan, JP, Zeng, W, Huang, GN, Worley, PF, Muallem, S

Nat Cell Biol 2007
18995841 STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

Zeng, W, Yuan, JP, Kim, MS, Choi, YJ, Huang, GN, Worley, PF, Muallem, S

Mol Cell 2008
22210847 The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells

Sundivakkam, PC, Freichel, M, Singh, V, Yuan, JP, Vogel, SM, Flockerzi, V, Malik, AB, Tiruppathi, C

Mol Pharmacol 2011
17224452 Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components

Ong, HL, Cheng, KT, Liu, X, Bandyopadhyay, BC, Paria, BC, Soboloff, J, Pani, B, Gwack, Y, Srikanth, S, Singh, BB, Gill, DL, Ambudkar, IS

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cation channel activity of STIM1:TRPC1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created