Reactome | TRPC1 translocates calcium from the extracellular region to the cytosol

TRPC1 translocates calcium from the extracellular region to the cytosol

Stable Identifier

R-HSA-2089943

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

Calcium Influx via TRPC1

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TRPC1 translocates calcium from the extracellular region to the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRPC1 forms a channel that transports Ca2+ across the plasma membrane. TRPC1 is gated by STIM1 (Ong et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17486119	STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels Yuan, JP, Zeng, W, Huang, GN, Worley, PF, Muallem, S	Nat Cell Biol	2007
18995841	STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction Zeng, W, Yuan, JP, Kim, MS, Choi, YJ, Huang, GN, Worley, PF, Muallem, S	Mol Cell	2008
22210847	The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells Sundivakkam, PC, Freichel, M, Singh, V, Yuan, JP, Vogel, SM, Flockerzi, V, Malik, AB, Tiruppathi, C	Mol Pharmacol	2011
17224452	Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components Ong, HL, Cheng, KT, Liu, X, Bandyopadhyay, BC, Paria, BC, Soboloff, J, Pani, B, Gwack, Y, Srikanth, S, Singh, BB, Gill, DL, Ambudkar, IS	J Biol Chem	2007