TRPA1 tetramer transports Ca2+ from extracellular region to cytosol

Stable Identifier
R-HSA-9701055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection (Moparthy et al. 2014, Paulsen et al. 2015). It acts as a sensor of chemical, thermal, mechanical and somotic stimuli (Zhang et al. 2008).

Literature References
PubMed ID Title Journal Year
25855297 Structure of the TRPA1 ion channel suggests regulatory mechanisms

Paulsen, CE, Armache, JP, Gao, Y, Cheng, Y, Julius, D

Nature 2015
20025796 Structure-functional intimacies of transient receptor potential channels

Latorre, R, Zaelzer, C, Brauchi, S

Q. Rev. Biophys. 2009
25389312 Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Moparthi, L, Survery, S, Kreir, M, Simonsen, C, Kjellbom, P, Högestätt, ED, Johanson, U, Zygmunt, PM

Proc. Natl. Acad. Sci. U.S.A. 2014
20716668 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Wu, LJ, Sweet, TB, Clapham, DE

Pharmacol. Rev. 2010
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
voltage-gated calcium channel activity of TRPA1 tetramer [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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