All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection (Moparthy et al. 2014, Paulsen et al. 2015). It acts as a sensor of chemical, thermal, mechanical and somotic stimuli (Zhang et al. 2008).
Paulsen, CE, Armache, JP, Gao, Y, Cheng, Y, Julius, D
Latorre, R, Zaelzer, C, Brauchi, S
Moparthi, L, Survery, S, Kreir, M, Simonsen, C, Kjellbom, P, Högestätt, ED, Johanson, U, Zygmunt, PM
Wu, LJ, Sweet, TB, Clapham, DE
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