All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection (Moparthy et al. 2014, Paulsen et al. 2015). It acts as a sensor of chemical, thermal, mechanical and somotic stimuli (Zhang et al. 2008).
Zaelzer, C, Brauchi, S, Latorre, R
Cheng, Y, Armache, JP, Gao, Y, Julius, D, Paulsen, CE
Survery, S, Kreir, M, Simonsen, C, Moparthi, L, Högestätt, ED, Kjellbom, P, Johanson, U, Zygmunt, PM
Clapham, DE, Wu, LJ, Sweet, TB
voltage-gated calcium channel activity of TRPA1 tetramer [plasma membrane]
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