SLC30A10 transports Mn2+ from cytosol to extracellular region

Stable Identifier
R-HSA-8959798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Manganese (Mn2+) is an essential metal that functions as a cofactor required for the activity of numerous essential enzymes but at at elevated levels, M2+n becomes toxic as it enhances oxidative stress, compromises mitochondrial function and induces cell death. Mn2+ is excreted by the liver in bile but excess Mn2+ preferentially accumulates in the basal ganglia, leading to the development of an irreversible and incurable Parkinsonian-like syndrome (Tuschl et al. 2012, Quadri et al. 2012, Leyva-Illades et al. 2014). SLC30A10 had previously been presumed to be a zinc transporter but now has been confirmed to function as an essential Mn2+ transporter in humans (Tuschi et al. 2012), mediating the efflux of Mn2+ from cells ( Leyva-Illades et al. 2014).

Literature References
PubMed ID Title Journal Year
22341971 Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease

Quadri, M, Federico, A, Zhao, T, Breedveld, GJ, Battisti, C, Delnooz, C, Severijnen, LA, Di Toro Mammarella, L, Mignarri, A, Monti, L, Sanna, A, Lu, P, Punzo, F, Cossu, G, Willemsen, R, Rasi, F, Oostra, BA, van de Warrenburg, BP, Bonifati, V

Am. J. Hum. Genet. 2012
25319704 SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity

Leyva-Illades, D, Chen, P, Zogzas, CE, Hutchens, S, Mercado, JM, Swaim, CD, Morrisett, RA, Bowman, AB, Aschner, M, Mukhopadhyay, S

J. Neurosci. 2014
22341972 Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man

Tuschl, K, Clayton, PT, Gospe, SM, Gulab, S, Ibrahim, S, Singhi, P, Aulakh, R, Ribeiro, RT, Barsottini, OG, Zaki, MS, Del Rosario, ML, Dyack, S, Price, V, Rideout, A, Gordon, K, Wevers, RA, Chong, WK, Mills, PB

Am. J. Hum. Genet. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
manganese ion transmembrane transporter activity of SLC30A10 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Rhea
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