The parathyroid glands play a role in ion homeostasis by sensing small changes in extracellular Ca2+ ion concentration. These glands express a cell surface receptor, calcium-sensing receptors (CaR) (Garrett JE et al, 1995) that is activated by increases in the concentration of extracellular calcium and by a variety of other cations. CaR serves as the primary physiological regulator of parathyroid hormone (PTH) secretion. CaR contributes to regulation of systemic calcium homeostasis by activation of Gq- (Kifor O et al, 1997) and Gi-linked (Kifor O et al, 2001) signaling pathways in the parathyroid glands, kidney and intestine.
Kifor, O, Diaz, R, Butters, R, Brown, EM
Garrett, JE, Capuano, IV, Hammerland, LG, Hung, BC, Brown, EM, Hebert, SC, Nemeth, EF, Fuller, F
Kifor, O, MacLeod, RJ, Diaz, R, Bai, M, Yamaguchi, T, Yao, T, Kifor, I, Brown, EM
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