Reactome | CASR binds Ca2+

CASR binds Ca2+

Stable Identifier

R-HSA-420724

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Calcium-sensing receptor binds calcium

ReviewStatus

5/5

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The parathyroid glands play a role in ion homeostasis by sensing small changes in extracellular Ca2+ ion concentration. These glands express a cell surface receptor, calcium-sensing receptors (CaR) (Garrett JE et al, 1995) that is activated by increases in the concentration of extracellular calcium and by a variety of other cations. CaR serves as the primary physiological regulator of parathyroid hormone (PTH) secretion. CaR contributes to regulation of systemic calcium homeostasis by activation of Gq- (Kifor O et al, 1997) and Gi-linked (Kifor O et al, 2001) signaling pathways in the parathyroid glands, kidney and intestine.

Literature References

PubMed ID	Title	Journal	Year
7759551	Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs Hebert, SC, Garrett, JE, Hammerland, LG, Brown, EM, Hung, BC, Fuller, F, Capuano, IV, Nemeth, EF	J Biol Chem	1995
9144337	The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells Brown, EM, Diaz, R, Kifor, O, Butters, R	J Bone Miner Res	1997
11208605	Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells Kifor, I, Bai, M, MacLeod, RJ, Brown, EM, Yao, T, Diaz, R, Kifor, O, Yamaguchi, T	Am J Physiol Renal Physiol	2001