Calcium-sensing receptor binds calcium

Stable Identifier
R-HSA-420724
Type
Reaction [binding]
Species
Homo sapiens
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The parathyroid glands play a role in ion homeostasis by sensing small changes in extracellular Ca2+ ion concentration. These glands express a cell surface receptor, calcium-sensing receptors (CaR) (Garrett JE et al, 1995) that is activated by increases in the concentration of extracellular calcium and by a variety of other cations. CaR serves as the primary physiological regulator of parathyroid hormone secretion. CaR contributes to regulation of systemic calcium homeostasis by activation of Gq- (Kifor O et al, 1997) and Gi-linked (Kifor O et al, 2001) signaling pathways in the parathyroid glands, kidney and intestine.

Literature References
PubMed ID Title Journal Year
9144337 The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells

Kifor, O, Diaz, R, Butters, R, Brown, EM

J Bone Miner Res 1997
7759551 Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs

Garrett, JE, Capuano, IV, Hammerland, LG, Hung, BC, Brown, EM, Hebert, SC, Nemeth, EF, Fuller, F

J Biol Chem 1995
11208605 Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells

Kifor, O, MacLeod, RJ, Diaz, R, Bai, M, Yamaguchi, T, Yao, T, Kifor, I, Brown, EM

Am J Physiol Renal Physiol 2001
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