Reactome | TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol

TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol

Stable Identifier

R-HSA-9858800

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol

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TRPV4 channels transport calcium ions across the plasma membrane (Strotmann et al. 2003, Nikolaev et al. 2019, and inferred from mouse and bovine homologs). Evidence from mice lacking Trpv4 indicates that Trpv4 is required for vasodilation in response to shear stress (Hartmannsgruber et al. 2007, Loot et al. 2008). TRPV4 channels are not directly activated by membrane stretch (Nikolaev et al. 2019) so the effect of shear stress appears to be indirect and TRPV4 acts downstream of the initial calcium influx caused by PIEZO1 channels to produce the sustained influx of calcium observed in response to shear stress (Swain and Liddle 2021). Calcium potentiates the calcium channel activity of TRPV4 through interaction between TRPV4 and Ca2+:calmodulin (Strotmann et al. 2003, 2010).

Literature References

PubMed ID	Title	Journal	Year
20485495	Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4 Plant, TD, Schöneberg, T, Semtner, M, Strotmann, R, Kepura, F	PLoS One	2010
31722978	Mammalian TRP ion channels are insensitive to membrane stretch Laver, DR, Ridone, P, Vásquez, V, Nikolaev, YA, Cordero-Morales, JF, Rohde, PR, Cox, CD, Martinac, B	J Cell Sci	2019
33298523	Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress Swain, SM, Liddle, RA	J Biol Chem	2021
12724311	Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site Plant, TD, Strotmann, R, Schultz, G	J Biol Chem	2003