SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+

Stable Identifier
Reaction [transition]
Homo sapiens
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The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. NCKX1 (SLC24A1) encodes an exchanger protein which is the most extensively studied member (Tucker et al. 1998). It is highly expressed in the eye. Other members are expressed in the brain and skin as well as the eye (Prinsen et al. 2000, Kraev et al. 2001, Li et al. 2002, Lamason et al. 2005).

Literature References
PubMed ID Title Journal Year
11294880 Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3

Quednau, BD, Cai, X, Kraev, A, Lytton, J, Yang, R, Philipson, KD, Leach, S, Perizzolo, M, Winkfein, R, Dong, H, Li, XF

J Biol Chem 2001
16357253 SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans

Shriver, MD, Mangini, NJ, Parra, EJ, Kittles, R, Cheng, KC, Jagadeeswaran, P, O'donnell, D, Zhao, W, Jurynec, MJ, Makalowska, I, Ning, G, Grunwald, DJ, Lamason, RL, Wong, AC, Mohideen, MA, McKeigue, PM, Humphreville, VR, Mao, X, Norton, HL, Canfield, VA, Moore, JL, Mest, JR, Aros, MC, Sinha, S, Humbert, JE

Science 2005
12379639 Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4

Kraev, AS, Lytton, J, Li, XF

J Biol Chem 2002
10662833 Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors

Szerencsei, RT, Prinsen, CF, Schnetkamp, PP

J Neurosci 2000
9856482 Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger

Walter, MA, Demetrick, DJ, Murthy, SK, Tucker, JE, Schnetkamp, PP, Friedman, JS, Winkfein, RJ

Hum Genet 1998
Catalyst Activity

calcium, potassium:sodium antiporter activity of SLC24A1-4 [plasma membrane]

Orthologous Events
Cross References
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