SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+

Stable Identifier
R-HSA-425678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. NCKX1 (SLC24A1) encodes an exchanger protein which is the most extensively studied member (Tucker et al. 1998). It is highly expressed in the eye. Other members are expressed in the brain and skin as well as the eye (Prinsen et al. 2000, Kraev et al. 2001, Li et al. 2002, Lamason et al. 2005).
Literature References
PubMed ID Title Journal Year
11294880 Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3

Kraev, A, Quednau, BD, Leach, S, Li, XF, Dong, H, Winkfein, R, Perizzolo, M, Cai, X, Yang, R, Philipson, KD, Lytton, J

J Biol Chem 2001
16357253 SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans

Lamason, RL, Mohideen, MA, Mest, JR, Wong, AC, Norton, HL, Aros, MC, Jurynec, MJ, Mao, X, Humphreville, VR, Humbert, JE, Sinha, S, Moore, JL, Jagadeeswaran, P, Zhao, W, Ning, G, Makalowska, I, McKeigue, PM, O'donnell, D, Kittles, R, Parra, EJ, Mangini, NJ, Grunwald, DJ, Shriver, MD, Canfield, VA, Cheng, KC

Science 2005
12379639 Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4

Li, XF, Kraev, AS, Lytton, J

J Biol Chem 2002
10662833 Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors

Prinsen, CF, Szerencsei, RT, Schnetkamp, PP

J Neurosci 2000
9856482 Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger

Tucker, JE, Winkfein, RJ, Murthy, SK, Friedman, JS, Walter, MA, Demetrick, DJ, Schnetkamp, PP

Hum Genet 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium, potassium:sodium antiporter activity of SLC24A1-4 [plasma membrane]

Physical Entity
SLC24A1-4 [plasma membrane] (Homo sapiens)
Activity
calcium, potassium:sodium antiporter activity (GO:0008273)
Orthologous Events
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Danio rerio)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-06-05)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-06-05)
Cite Us!