Ficolin-1 binds to molecular patterns on the target cell surface

Stable Identifier
Homo sapiens
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Ficolin-1 (M-ficolin or FCN1) was shown to localize at the cell surface of circulating monocytes and granulocytes, despite lacking an obvious transmembrane domain, (Teh C et al. 2000; Honore C et al. 2010). Ficolin-1 has also been found in human plasma (Honore C et al. 2008; Wittenborn T et al. 2010; Kjaer TR et al. 2011). Monocytes and macrophages, but not immature dendritic cells were reported to secrete Ficolin-1 into the serum (Honore C et al. 2010). Moreover, early studies revealed its presence in secretory granules of peripheral blood monocytes and granulocytes (Liu Y et al. 2005). Soluble Ficolin-1 was found to form a complex with MASP2, while cell surface-bound Ficolin-1 did not associate with MASP (Honore C et al. 2010; Kjaer TR et al. 2011).

Ficolin-1 specifically recognizes sialic acid and can bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) (Garlatti V et al. 2007; Gout E et al. 2010; Kjaer TR et al. 2011).

Literature References
PubMed ID Title Journal Year
20375634 Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma

Wittenborn, T, Nielsen, HJ, Jensen, L, Jensenius, JC, Thiel, S

J Innate Immun 2010
17897951 Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch

Reiser, JB, Martin, L, Thielens, NM, Garlatti, V, Gaboriaud, C, Arlaud, GJ, Gout, E, Fujita, T

J. Biol. Chem. 2007
20032467 Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin

Martin, L, Arlaud, GJ, Dumestre-Pérard, C, Garlatti, V, Lacroix, M, Gaboriaud, C, Cesbron, JY, Thielens, NM, Lunardi, T, Smith, DF, Gout, E

J Biol Chem 2010
16116205 Human M-ficolin is a secretory protein that activates the lectin complement pathway

Endo, Y, Nakata, M, Wada, I, Matsushita, M, Munakata, M, Liu, Y, Inoue, K, Fujita, T, Iwaki, D

J. Immunol. 2005
11012776 M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli

Le, Y, Lu, J, Teh, C, Lee, SH

Immunology 2000
20400674 Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

Rørvig, S, Honoré, C, Borregaard, N, Garred, P, Hummelshøj, T, Skjoedt, MO

J. Leukoc. Biol. 2010
21730084 Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association

Sørensen, UB, Hansen, AG, Nielsen, O, Kjaer, TR, Jensenius, JC, Thiel, S

J. Leukoc. Biol. 2011
18343499 The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma

Rørvig, S, Madsen, HO, Honoré, C, Borregaard, N, Garred, P, Hummelshøj, T, Munthe-Fog, L

Mol. Immunol. 2008
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