TRPs transport extracellular Ca2+ to cytosol

Stable Identifier
R-HSA-3295579
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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TRPs transport extracellular Ca2+ to cytosol
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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010).
Literature References
PubMed ID Title Journal Year
20025796 Structure-functional intimacies of transient receptor potential channels

Zaelzer, C, Brauchi, S, Latorre, R

Q. Rev. Biophys. 2009
20716668 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Clapham, DE, Wu, LJ, Sweet, TB

Pharmacol. Rev. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium channel activity of TRPs [plasma membrane]

Physical Entity
TRPs [plasma membrane] (Homo sapiens)
Activity
calcium channel activity (GO:0005262)
This event is regulated
Positively by
Regulator
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
Orthologous Events
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)
TRPs transport extracellular Ca2+ to cytosol (Danio rerio)
TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)
TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)
TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)
TRPs transport extracellular Ca2+ to cytosol (Mus musculus)
TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)
TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)
TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)
TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2013-04-17)
Reviewed
He, L  (2013-07-16)
Created
Jassal, B  (2013-04-17)
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