Activation of Ca-permeable Kainate receptors

Stable Identifier
R-HSA-451311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Ca-permeable Kainate receptors
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
Literature References
PubMed ID Title Journal Year
9625352 Functional AMPA/kainate receptors in human embryonic and foetal central nervous system

Bardoul, M, König, N, Levallois, C

J Chem Neuroanat 1998
8782898 Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors

Giordano, T, Cortes-Burgos, L, Carver, JM, Shu, J, Howe, JR, Mansson, PE, Zhou, LM

Brain Res 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ligand-gated monoatomic ion channel activity of Kainate receptor-glutamate complex [plasma membrane]

Physical Entity
Kainate receptor-glutamate complex [plasma membrane] (Homo sapiens)
Activity
ligand-gated monoatomic ion channel activity (GO:0015276)
Orthologous Events
Activation of Ca-permeable Kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
Activation of Ca-permeable Kainate receptors (Canis familiaris)
Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)
Activation of Ca-permeable Kainate receptors (Gallus gallus)
Activation of Ca-permeable Kainate receptors (Mus musculus)
Activation of Ca-permeable Kainate receptors (Rattus norvegicus)
Activation of Ca-permeable Kainate receptors (Sus scrofa)
Cross References
Rhea
Authored
Mahajan, SS  (2010-01-15)
Reviewed
Tukey, D  (2009-11-18)
Created
Mahajan, SS  (2010-01-05)
Cite Us!