Activation of Ca-permeable Kainate receptors

Stable Identifier
R-HSA-451311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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Activation of Ca-permeable Kainate receptors
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Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.

Literature References
PubMed ID Title Journal Year
8782898 Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors

Carver, JM, Mansson, PE, Cortes-Burgos, L, Shu, J, Zhou, LM, Howe, JR, Giordano, T

Brain Res 1996
9625352 Functional AMPA/kainate receptors in human embryonic and foetal central nervous system

Bardoul, M, Levallois, C, König, N

J Chem Neuroanat 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ligand-gated ion channel activity of Kainate receptor-glutamate complex [plasma membrane]
Physical Entity
Kainate receptor-glutamate complex [plasma membrane]
Activity
ligand-gated ion channel activity (0015276)
Orthologous Events
Activation of Ca-permeable Kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate receptors (Canis familiaris)
Activation of Ca-permeable Kainate receptors (Danio rerio)
Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)
Activation of Ca-permeable Kainate receptors (Gallus gallus)
Activation of Ca-permeable Kainate receptors (Mus musculus)
Activation of Ca-permeable Kainate receptors (Rattus norvegicus)
Activation of Ca-permeable Kainate receptors (Sus scrofa)
Activation of Ca-permeable Kainate receptors (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2010-01-15)
Reviewed
Tukey, D  (2009-11-18)
Created
Mahajan, SS  (2010-01-05)
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