Reactome | Activation of Ca-permeable Kainate receptors

Activation of Ca-permeable Kainate receptors

Stable Identifier

R-HSA-451311

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Ionotropic activity of kainate receptors (Homo sapiens)
        
        Activation of Ca-permeable Kainate Receptor (Homo sapiens)
        
        Activation of Ca-permeable Kainate receptors (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Activation of Ca-permeable Kainate receptors

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.

Literature References

PubMed ID	Title	Journal	Year
8782898	Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors Carver, JM, Mansson, PE, Cortes-Burgos, L, Shu, J, Zhou, LM, Howe, JR, Giordano, T	Brain Res	1996
9625352	Functional AMPA/kainate receptors in human embryonic and foetal central nervous system Bardoul, M, Levallois, C, König, N	J Chem Neuroanat	1998