Reactome | Activation of Ca-permeable Kainate receptors

Activation of Ca-permeable Kainate receptors

Stable Identifier

R-HSA-451311

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Ionotropic activity of kainate receptors (Homo sapiens)
        
        Activation of Ca-permeable Kainate Receptor (Homo sapiens)
        
        Activation of Ca-permeable Kainate receptors (Homo sapiens)

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Activation of Ca-permeable Kainate receptors

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Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.

Literature References

PubMed ID	Title	Journal	Year
9625352	Functional AMPA/kainate receptors in human embryonic and foetal central nervous system Bardoul, M, Levallois, C, König, N	J Chem Neuroanat	1998
8782898	Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors Carver, JM, Mansson, PE, Cortes-Burgos, L, Shu, J, Zhou, LM, Howe, JR, Giordano, T	Brain Res	1996