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tissue factor (TF) + factor VII (F7) -> TF:F7 complex
Stable Identifier
R-HSA-140783
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
Synonyms
formation of TF:F7 complex
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)
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Coagulation factor VII circulates in plasma mostly in the zymogen form (FVII); about 1% of plasma FVII is found in the active form (FVIIa) (Morrissey JH et al. 1993). Initiation of coagulation begins by exposure of blood (which contains both zymogen FVII and activated FVIIa) to tissue factor (TF) in the extravascular space at an injury site and formation of the Ca2+-dependent complex between TF and plasma FVII/FVIIa (Kelley RF et al. 2004; Ruf W et al. 1991). The TF:FVII zymogen complex has low but measurable proteolytic activity on factor X, suggesting that this complex initiates TF-dependent clotting through a minimal generation of factor Xa, which in turn catalyzes the activation of FVII from plasma. (Rao LV et al. 1986). As factor VIIa accumulates, TF:FVIIa complexes also form, accelerating the process (Nemerson 1988). Formation of the TF:FVIIa complex greatly increases the enzymatic activity of FVIIa via allosteric interactions between TF and FVIIa, as revealed by a 20- to 100-fold increase in the rate of amidolysis of small, chromogenic peptidyl substrates (Broze GJ Jr & Majerus PW.1980; Butenas S et al. 1994; Higashi S et al. 1996). A second model, building on the observation that normal plasma contains low levels of activated FVIIa constitutively, suggests that complexes with FVIIa form immediately at the onset of clotting (Rapaport and Rao 1995). The two models are not mutually exclusive, and in any event, the central roles of TF and FVIIa in generating an initial supply of factors IXa and Xa, and the self-limiting nature of the process due to the action of TFPI, are all well-established.
Literature References
PubMed ID
Title
Journal
Year
1874730
Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions
Kalnik, MW
,
Edgington, TS
,
Ruf, W
,
Lund-Hansen, T
J. Biol. Chem.
1991
3527261
Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine
Gentry, R
,
Bach, R
,
Nemerson, Y
Biochemistry
1986
Participants
Input
10xCbxE-F7(61-466):Ca2+ [extracellular region]
(Homo sapiens)
PalmC, 2HC-F3 [plasma membrane]
(Homo sapiens)
Output
TF:F7 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
This event is regulated
Positively by
Regulator
Ca2+ [extracellular region]
Orthologous Events
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Canis familiaris)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)
Authored
D'Eustachio, P (2004-08-24)
Created
D'Eustachio, P (2004-08-24)
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