S100A8:S100A9:Ca2+:Zn2+ [extracellular region]

Stable Identifier
R-HSA-8944189
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
calprotectin heterotetramer
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17553524 The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins

Skerra, A, Brueckner, F, Korndörfer, IP

J. Mol. Biol. 2007
10976885 Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysis

Strupat, K, Rogniaux, H, Vogl, T, Roth, J, Van Dorsselaer, A

J. Am. Soc. Mass Spectrom. 2000
16690079 Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity

Roth, J, Strupat, K, Sorg, C, Vogl, T, Reichelt, R, Leukert, N

J. Mol. Biol. 2006
23431180 Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

Hench, L, Skaar, EP, Sugitani, N, Fritz, G, Betz, C, Zhang, Y, Rathi, S, Damo, SM, Kehl-Fie, TE, Chazin, WJ, Murphy, WJ, Holt, ME

Proc. Natl. Acad. Sci. U.S.A. 2013
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