Reactome | S100A8:S100A9:Ca2+:Zn2+ [extracellular region]

Stable Identifier

R-HSA-8944189

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Synonyms

calprotectin heterotetramer

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Literature References

PubMed ID	Title	Journal	Year
10976885	Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysis Strupat, K, Rogniaux, H, Van Dorsselaer, A, Roth, J, Vogl, T	J. Am. Soc. Mass Spectrom.	2000
23431180	Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens Damo, SM, Kehl-Fie, TE, Sugitani, N, Holt, ME, Rathi, S, Murphy, WJ, Zhang, Y, Betz, C, Hench, L, Fritz, G, Skaar, EP, Chazin, WJ	Proc. Natl. Acad. Sci. U.S.A.	2013
16690079	Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity Leukert, N, Vogl, T, Strupat, K, Reichelt, R, Sorg, C, Roth, J	J. Mol. Biol.	2006
17553524	The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins Korndörfer, IP, Brueckner, F, Skerra, A	J. Mol. Biol.	2007

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