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activated thrombin (factor IIa) [extracellular region]
Stable Identifier
R-MMU-156786
Type
Complex
Species
Mus musculus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
Common Pathway of Fibrin Clot Formation (Mus musculus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
Factor IIa inhibitors (compounds) binds IIa (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide) binds IIa (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Thrombin binding to GP1b:IX:V (Mus musculus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Complement cascade (Mus musculus)
Regulation of Complement cascade (Mus musculus)
Thrombin, ELANE cleave C5 (Mus musculus)
Activated thrombin, (ELANE) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
The Ligand:GPCR:Gq complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Peptide ligand-binding receptors (Mus musculus)
Proteinase-activated receptors can bind thrombin (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
Ca2+ [extracellular region]
F2 [extracellular region]
(Mus musculus)
F2 [extracellular region]
(Mus musculus)
Participates
as an input of
Thrombin binding to GP1b:IX:V (Mus musculus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
Factor IIa inhibitors (compounds) binds IIa (Mus musculus)
Factor IIa inhibitors (peptide) binds IIa (Mus musculus)
Proteinase-activated receptors can bind thrombin (Mus musculus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
as a component of
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
as an output of
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)
as a member of
Activated thrombin, (ELANE) [extracellular region] (Mus musculus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
Inferred From
activated thrombin (factor IIa) [extracellular region]
(Homo sapiens)
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