tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex

Stable Identifier
R-HSA-140748
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
formation of TF:F7a complex
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Tissue factor exposed at the endothelial cell surface forms a Ca2+-dependent complex with factor VIIa (FVIIa, activated FVII) from the plasma (Butenas S et al. 1994; Sabharwal AK et al. 1995; Banner DW et al. 1996; Bajaj SP et al. 2006; Persson E & Olsen OH 2011; Madsen JJ et al. 2015). FVIIa is allosterically activated by TF, which increases the amidolytic activity of FVIIa several-fold by restructuring the active site region (Butenas S et al. 1994; Higashi S et al. 1996; Sorensen AB et al. 2019). FVIIa, bound to TF at the endothelial cell surface, catalyzes the formation of activated factor IXa (FIXa) and FXa with high efficiency leading to thrombin generation and fibrin formation (Vadivel K & Bajaj SP 2012).

Literature References
PubMed ID Title Journal Year
22652793 Structural biology of factor VIIa/tissue factor initiated coagulation

Bajaj, SP, Vadivel, K

Front Biosci (Landmark Ed) 2012
31003762 Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures

Olsen, OH, Persson, E, Frimurer, TM, Overgaard, MT, Gandhi, PS, Sorensen, AB, Madsen, JJ

Biophys. J. 2019
8598903 The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

Kirchhofer, D, Winkler, FK, Chene, C, Konigsberg, WH, Guha, A, D'Arcy, A, Nemerson, Y, Banner, DW

Nature 1996
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