Reactome | tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex

tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex

Stable Identifier

R-HSA-140748

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

formation of TF:F7a complex

ReviewStatus

5/5

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tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex

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Tissue factor exposed at the endothelial cell surface forms a Ca2+-dependent complex with factor VIIa (FVIIa, activated FVII) from the plasma (Butenas S et al. 1994; Sabharwal AK et al. 1995; Banner DW et al. 1996; Bajaj SP et al. 2006; Persson E & Olsen OH 2011; Madsen JJ et al. 2015). FVIIa is allosterically activated by TF, which increases the amidolytic activity of FVIIa several-fold by restructuring the active site region (Butenas S et al. 1994; Higashi S et al. 1996; Sorensen AB et al. 2019). FVIIa, bound to TF at the endothelial cell surface, catalyzes the formation of activated factor IXa (FIXa) and FXa with high efficiency leading to thrombin generation and fibrin formation (Vadivel K & Bajaj SP 2012).

Literature References

PubMed ID	Title	Journal	Year
22652793	Structural biology of factor VIIa/tissue factor initiated coagulation Bajaj, SP, Vadivel, K	Front Biosci (Landmark Ed)	2012
31003762	Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures Olsen, OH, Persson, E, Frimurer, TM, Overgaard, MT, Gandhi, PS, Sorensen, AB, Madsen, JJ	Biophys. J.	2019
8598903	The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor Kirchhofer, D, Winkler, FK, Chene, C, Konigsberg, WH, Guha, A, D'Arcy, A, Nemerson, Y, Banner, DW	Nature	1996