Reactome | Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Stable Identifier

R-HSA-629595

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)

General

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Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

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Acetylcholine binding activates postsynaptic acetylchloine receptors that show Ca2+ currents which facilitate the process of long term potentiation (LTP).

Literature References

PubMed ID	Title	Journal	Year
10945867	Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine Grottick, AJ, Trube, G, Corrigall, WA, Huwyler, J, Malherbe, P, Wyler, R, Higgins, GA	J Pharmacol Exp Ther	2000
12810063	Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors Fucile, S, Renzi, M, Lax, P, Eusebi, F	Cell Calcium	2003

Participants

Input

Ca2+ [extracellular region]

Output

Ca2+ [cytosol]

Participates

as an event of

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)

Catalyst Activity

ligand-gated monoatomic ion channel activity of O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane]

Physical Entity

O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)

Activity

ligand-gated monoatomic ion channel activity (GO:0015276)

Orthologous Events

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)