Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Stable Identifier
R-HSA-629595
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors
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Acetylcholine binding activates postsynaptic acetylchloine receptors that show Ca2+ currents which facilitate the process of long term potentiation (LTP).

Literature References
PubMed ID Title Journal Year
10945867 Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine

Grottick, AJ, Wyler, R, Trube, G, Higgins, GA, Malherbe, P, Huwyler, J, Corrigall, WA

J Pharmacol Exp Ther 2000
12810063 Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors

Lax, P, Eusebi, F, Fucile, S, Renzi, M

Cell Calcium 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ligand-gated ion channel activity of O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane]

Physical Entity
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Activity
ligand-gated ion channel activity (GO:0015276)
Orthologous Events
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2010-04-27)
Reviewed
Restituito, S  (2008-11-27)
Wen, H  (2020-01-24)
Created
Mahajan, SS  (2010-04-27)
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