Reactome | Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Stable Identifier

R-HSA-629595

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)

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Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors

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Acetylcholine binding activates postsynaptic acetylchloine receptors that show Ca2+ currents which facilitate the process of long term potentiation (LTP).

Literature References

PubMed ID	Title	Journal	Year
12810063	Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors Fucile, S, Renzi, M, Lax, P, Eusebi, F	Cell Calcium	2003
10945867	Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine Grottick, AJ, Trube, G, Corrigall, WA, Huwyler, J, Malherbe, P, Wyler, R, Higgins, GA	J Pharmacol Exp Ther	2000