Reactome | HTR3 pentamers:5HT transport Na+,K+,Ca2+

HTR3 pentamers:5HT transport Na+,K+,Ca2+

Stable Identifier

R-HSA-975311

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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HTR3 pentamers:5HT transport Na+,K+,Ca2+

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The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015) Although heterpentamer composition can vary between the two receptors binding, the example 2xHTR3A:3xHTR3(B-E) is shown here. Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 complex opens the channel, which in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al. 1995, Davies et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9950429	The 5-HT3B subunit is a major determinant of serotonin-receptor function Kirkness, EF, Peters, JA, Davies, PA, Pistis, M, Hales, TG, Lambert, JJ, Hanna, MC	Nature	1999
26238288	Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery Jiang, Y, Cheng, H, Wu, ZS, Melcher, K, Xu, HE	Acta Pharmacol. Sin.	2015
17392525	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E Moller, D, Walstab, J, Rietdorf, J, Kapeller, J, Niesler, B, Combrink, S, Rappold, G, Gothert, M, Bonisch, H, Bruss, M	Mol Pharmacol	2007
18761359	The 5-HT3 receptor--the relationship between structure and function Peters, JA, Barnes, NM, Lummis, SC, Hales, TG	Neuropharmacology	2009
16116092	Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors Henderson, RM, Herbert, P, Martin, IL, Edwardson, JM, Barrera, NP	Proc. Natl. Acad. Sci. U.S.A.	2005
7565620	Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species Miyake, A, Akuzawa, S, Takemoto, Y, Mochizuki, S	Mol Pharmacol	1995