The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015) Although heterpentamer composition can vary between the two receptors binding, the example 2xHTR3A:3xHTR3(B-E) is shown here. Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 complex opens the channel, which in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al. 1995, Davies et al. 1999).
Kirkness, EF, Peters, JA, Davies, PA, Pistis, M, Hales, TG, Lambert, JJ, Hanna, MC
Jiang, Y, Cheng, H, Wu, ZS, Melcher, K, Xu, HE
Moller, D, Walstab, J, Rietdorf, J, Kapeller, J, Niesler, B, Combrink, S, Rappold, G, Gothert, M, Bonisch, H, Bruss, M
Peters, JA, Barnes, NM, Lummis, SC, Hales, TG
Henderson, RM, Herbert, P, Martin, IL, Edwardson, JM, Barrera, NP
Miyake, A, Akuzawa, S, Takemoto, Y, Mochizuki, S
serotonin-gated cation-selective channel activity of HTR3 pentamers:5HT [plasma membrane]
© 2023 Reactome
