HTR3 pentamers:5HT transport Na+,K+,Ca2+

Stable Identifier
Reaction [transition]
Homo sapiens
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The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015) Although heterpentamer composition can vary between the two receptors binding, the example 2xHTR3A:3xHTR3(B-E) is shown here. Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 complex opens the channel, which in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al. 1995, Davies et al. 1999).

Literature References
PubMed ID Title Journal Year
26238288 Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

Wu, ZS, Cheng, H, Jiang, Y, Melcher, K, Xu, HE

Acta Pharmacol. Sin. 2015
9950429 The 5-HT3B subunit is a major determinant of serotonin-receptor function

Davies, PA, Pistis, M, Hanna, MC, Peters, JA, Lambert, JJ, Hales, TG, Kirkness, EF

Nature 1999
17392525 Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E

Niesler, B, Walstab, J, Combrink, S, Moller, D, Kapeller, J, Rietdorf, J, Bonisch, H, Gothert, M, Rappold, G, Bruss, M

Mol Pharmacol 2007
18761359 The 5-HT3 receptor--the relationship between structure and function

Barnes, NM, Hales, TG, Lummis, SC, Peters, JA

Neuropharmacology 2009
16116092 Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors

Barrera, NP, Herbert, P, Henderson, RM, Martin, IL, Edwardson, JM

Proc. Natl. Acad. Sci. U.S.A. 2005
7565620 Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species

Miyake, A, Mochizuki, S, Takemoto, Y, Akuzawa, S

Mol Pharmacol 1995
Participant Of
Catalyst Activity
Catalyst Activity
serotonin-gated cation-selective channel activity of HTR3 pentamers:5HT [plasma membrane]
Physical Entity
Orthologous Events
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