Serum amyloid P-component forms homopentamers

Stable Identifier
R-HSA-976723
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Serum amyloid P-component forms homopentamers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Serum amyloid P component (SAP) is a member of the pentraxin family, characterized by the formation of pentameric ring structures. Each member of the ring has two associated calcium ions. SAP is an acute phase reactant, highly induced by IL-6. It has 50% homology with the related C-reactive peptide.
Literature References
PubMed ID Title Journal Year
8114934 Structure of pentameric human serum amyloid P component

Emsley, J, White, HE, O'Hara, BP, Oliva, G, Srinivasan, N, Tickle, IJ, Blundell, TL, Pepys, MB, Wood, SP

Nature 1994
Participants
Input
Output
Participates
as an event of
Authored
Jupe, S  (2010-10-15)
Reviewed
Perry, G  (2011-04-08)
Perry, G  (2015-11-09)
Created
Jupe, S  (2010-10-13)
Cite Us!