Ficolin-2 binds to molecular patterns on the target cell surface

Stable Identifier
Reaction [binding]
Homo sapiens
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Human ficolin-2 (L-ficolin, P35, FCN2) is synthesised in the liver and secreted into the bloodstream where it recognizes various capsulated bacteria and exhibits binding specificity for diverse ligands such as lipoteichoic acid, 1,3-beta-d-glucan and acetylated compounds (Lynch et al. 2004, Aoyagi et al. 2008, Ma et al. 2004, Garlatti et al. 2007, Gout et al. 2010). Ficolin-2 also binds to apoptotic HL60, U937 and Jurkat cells (Kuraya et al. 2005).

Literature References
PubMed ID Title Journal Year
15804047 Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation

Liu, X, Matsushita, M, Kuraya, M, Ming, Z, Fujita, T

Immunobiology 2005
17938215 L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway

Adderson, EE, Matsushita, M, Rubens, CE, Aoyagi, Y, Min, JG, Takahashi, S, Okuwaki, Y, Fujita, T, Bohnsack, JF

Infect. Immun. 2008
20032467 Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin

Martin, L, Arlaud, GJ, Dumestre-PĂ©rard, C, Garlatti, V, Lacroix, M, Gaboriaud, C, Cesbron, JY, Thielens, NM, Lunardi, T, Smith, DF, Gout, E

J Biol Chem 2010
18596036 Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins

Martin, L, Teillet, F, Arlaud, GJ, Lacroix, M, Gaboriaud, C, Thielens, NM

J Biol Chem 2008
10679061 Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease

Matsushita, M, Endo, Y, Fujita, T

J. Immunol. 2000
20375619 Structural insights into the recognition properties of human ficolins

Martin, L, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Arlaud, GJ, Gout, E

J Innate Immun 2010
17215869 Structural insights into the innate immune recognition specificities of L- and H-ficolins

Endo, Y, Martin, L, Fontecilla-Camps, JC, Matsushita, M, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Belloy, N, Arlaud, GJ, Fujita, T

EMBO J. 2007
14707097 L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement

Roscher, S, Kuraya, M, Matsushita, M, Morath, S, Hartung, T, Schwaeble, WJ, Fujita, T, Maennel, DN, Lynch, NJ

J. Immunol. 2004
15078867 Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement

Zhao, M, Ma, YG, Matsushita, M, Park, JW, Lee, BL, Fujita, T, Cho, MY

J. Biol. Chem. 2004
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