Reactome | Ficolin-2 binds to molecular patterns on the target cell surface

Ficolin-2 binds to molecular patterns on the target cell surface

Stable Identifier

R-HSA-2855054

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
        
        Ficolin-2 binds to molecular patterns on the target cell surface (Homo sapiens)

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Ficolin-2 binds to molecular patterns on the target cell surface

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Human ficolin-2 (L-ficolin, P35, FCN2) is synthesised in the liver and secreted into the bloodstream where it recognizes various capsulated bacteria and exhibits binding specificity for diverse ligands such as lipoteichoic acid, 1,3-beta-d-glucan and acetylated compounds (Lynch et al. 2004, Aoyagi et al. 2008, Ma et al. 2004, Garlatti et al. 2007, Gout et al. 2010). Ficolin-2 also binds to apoptotic HL60, U937 and Jurkat cells (Kuraya et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15804047	Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation Liu, X, Matsushita, M, Kuraya, M, Ming, Z, Fujita, T	Immunobiology	2005
17938215	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway Adderson, EE, Matsushita, M, Rubens, CE, Aoyagi, Y, Min, JG, Takahashi, S, Okuwaki, Y, Fujita, T, Bohnsack, JF	Infect. Immun.	2008
20032467	Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin Martin, L, Arlaud, GJ, Dumestre-Pérard, C, Garlatti, V, Lacroix, M, Gaboriaud, C, Cesbron, JY, Thielens, NM, Lunardi, T, Smith, DF, Gout, E	J Biol Chem	2010
18596036	Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins Martin, L, Teillet, F, Arlaud, GJ, Lacroix, M, Gaboriaud, C, Thielens, NM	J Biol Chem	2008
10679061	Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease Matsushita, M, Endo, Y, Fujita, T	J. Immunol.	2000
20375619	Structural insights into the recognition properties of human ficolins Martin, L, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Arlaud, GJ, Gout, E	J Innate Immun	2010
17215869	Structural insights into the innate immune recognition specificities of L- and H-ficolins Endo, Y, Martin, L, Fontecilla-Camps, JC, Matsushita, M, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Belloy, N, Arlaud, GJ, Fujita, T	EMBO J.	2007
14707097	L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement Roscher, S, Kuraya, M, Matsushita, M, Morath, S, Hartung, T, Schwaeble, WJ, Fujita, T, Maennel, DN, Lynch, NJ	J. Immunol.	2004
15078867	Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement Zhao, M, Ma, YG, Matsushita, M, Park, JW, Lee, BL, Fujita, T, Cho, MY	J. Biol. Chem.	2004