P2X1-mediated entry of Ca++ from plasma

Stable Identifier
R-HSA-139855
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The P2X1 receptor is a rapidly-desensitized ATP-gated cation channel with relatively high calcium permeability. It has highest expression in smooth muscle and platelets. P2X1 receptor activation cannot induce platelet aggregation but does contribute to aggregation seen in response to collagen (Oury et al. 2001; Hechler et al. 2003). The role of P2X1 is more significant under flow conditions characterized by high shear stress (Hechler et al. 2003; Oury et al. 2004). P2X1 knockout mice havereduced incidence of thrombosis of mesenteric arterioles triggered by laser-induced vessel wall injury and are resistant to the acute systemic thromboembolism induced by infusion of a mixture of collagen and adrenaline (Hechler et al. 2003). Conversely, increased systemic thrombosis has been reported in mice overexpressing the human P2X1 receptor (Oury et al. 2003). P2X1 binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, controlling sympathetic vasoconstriction in small arteries, arterioles and vas deferens.

Literature References
PubMed ID Title Journal Year
2457808 Calcium channels in thrombin-activated human platelet membrane

Zschauer, A, van, Breemen C, Buhler, FR, Nelson, MT

Nature 1988
9565569 P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression

Sun, B, Li, J, Okahara, K, Kambayashi, J

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium channel activity of P2X purinoreceptors:ATP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created
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