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p-Y599,Y605-EPHA1 [plasma membrane]
Stable Identifier
R-HSA-3928336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
p-EPHs bind VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF binds EPHA (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21709 EPHA1
Gene Names
EPHA1, EPH, EPHT, EPHT1
Chain
signal peptide:1-25, chain:26-976
Reference Genes
BioGPS Gene:2041 EPHA1
COSMIC (genes):EPHA1 EPHA1
CTD Gene:2041 EPHA1
dbSNP Gene:2041 EPHA1
ENSEMBL:ENSG00000146904 EPHA1
ENSEMBL:ENSG00000284816 EPHA1
HGNC:3385 EPHA1
KEGG Gene (Homo sapiens):2041 EPHA1
Monarch:2041 EPHA1
NCBI Gene:2041 EPHA1
OMIM:179610 EPHA1
UCSC:P21709 EPHA1
Reference Transcript
RefSeq:NM_005232.4 EPHA1
Other Identifiers
0006400039
1108_s_at
11723373_a_at
11751296_a_at
17063948
2041
205977_s_at
3077323
3077324
3077325
3077326
3077328
3077329
3077330
3077331
3077333
3077334
3077337
3077340
3077343
3077344
3077345
3077346
3077347
3077348
3077349
3077350
3077351
3077355
3077357
3077360
3077361
8143575
A_23_P157333
GE62812
GO:0000166
GO:0000902
GO:0001525
GO:0001954
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005005
GO:0005515
GO:0005524
GO:0005575
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006469
GO:0007010
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007275
GO:0007411
GO:0008150
GO:0008283
GO:0008284
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0030335
GO:0030336
GO:0032991
GO:0033674
GO:0034446
GO:0035019
GO:0040011
GO:0043005
GO:0043087
GO:0043167
GO:0043235
GO:0045766
GO:0046777
GO:0048013
GO:0048646
GO:0048856
GO:0048870
GO:0051496
GO:0090630
ILMN_1664265
M18391_s_at
PH_hs_0005023
TC07001971.hg
g4885208_3p_a_at
Participant Of
hasMember
p-EPHAs [plasma membrane]
Other forms of this molecule
EPHA1 [plasma membrane]
Inferred To
phospho-epha2a [plasma membrane] (Danio rerio)
phospho-EPHA1 [plasma membrane] (Bos taurus)
phospho-EPHA1 [plasma membrane] (Canis familiaris)
phospho-EPHA1 [plasma membrane] (Gallus gallus)
phospho-EPHA1 [plasma membrane] (Sus scrofa)
phospho-Epha1 [plasma membrane] (Mus musculus)
phospho-Epha1 [plasma membrane] (Rattus norvegicus)
Homologues of p-Y599,Y605-EPHA1 [plasma membrane] (Danio rerio)
phospho-vab-1 [plasma membrane] (Caenorhabditis elegans)
phospho-Eph [plasma membrane] (Drosophila melanogaster)
phospho-epha2b [plasma membrane] (Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 599
Coordinate
599
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 605
Coordinate
605
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_005223.4
ZINC - World Drugs
EPHA1_HUMAN
OpenTargets
ENSG00000146904
ZINC - FDA approved
EPHA1_HUMAN
ZINC - Substances
EPHA1_HUMAN
ZINC - Biogenic
EPHA1_HUMAN
ZINC target
P21709
PRO
P21709
PDB
3KKA
,
3HIL
,
2K1L
,
2K1K
ZINC - Investigational
EPHA1_HUMAN
GeneCards
P21709
HPA
ENSG00000146904-EPHA1
Ensembl
ENSP00000275815
,
ENSP00000494931
,
ENST00000275815
,
ENST00000645847
,
ENSG00000284816
,
ENSG00000146904
ZINC - Predictions - Purchasable
EPHA1_HUMAN
HMDB Protein
HMDBP01345
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-1108795 NPM
0.499
3
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