Reactome | SLC31A1 [plasma membrane]

SLC31A1 [plasma membrane]

Stable Identifier

R-HSA-437299

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

hCTR1, High affinity copper uptake protein 1, COPT1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15431 SLC31A1

Gene Names

SLC31A1, COPT1, CTR1

Chain

chain:1-190, chain:43-190

Reference Genes

BioGPS Gene:1317 SLC31A1

COSMIC (genes):SLC31A1 SLC31A1

CTD Gene:1317 SLC31A1

dbSNP Gene:1317 SLC31A1

ENSEMBL:ENSG00000136868 SLC31A1

HGNC:11016 SLC31A1

KEGG:hsa:1317 SLC31A1

Monarch:1317 SLC31A1

NCBI Gene:1317 SLC31A1

OMIM:603085 SLC31A1

UCSC:O15431 SLC31A1

Reference Transcript

RefSeq:NM_001859.4 SLC31A1

Other Identifiers

11732335_at

11732336_at

11747792_a_at

11759701_at

1317

17088173

203971_PM_at

203971_at

235013_PM_at

235013_at

236217_PM_at

236217_at

2705741

3023462

3185521

3185523

3185528

3185535

3185536

3185537

3185538

3185539

3185540

3185541

3185543

3185544

3185545

3185546

3185547

3185548

3185549

40364_at

51237_at

74377_at

8157270

8157281

A_14_P129347

A_23_P253405

A_24_P252667

A_24_P321068

A_24_P928901

GE59495

GO:0001525

GO:0005375

GO:0005507

GO:0005515

GO:0005768

GO:0005770

GO:0005886

GO:0006811

GO:0006825

GO:0006878

GO:0014704

GO:0015080

GO:0015677

GO:0015679

GO:0016020

GO:0016323

GO:0016324

GO:0031901

GO:0031902

GO:0035434

GO:0036324

GO:0042802

GO:0042908

GO:0042910

GO:0051259

GO:0051649

GO:0055037

GO:0055038

GO:0055085

GO:0065003

GO:1902601

HMNXSV003012793

Hs.129005.0.A1_3p_at

Hs.271914.0.A1_3p_at

ILMN_1804562

PH_hs_0019597

TC09000572.hg

g4507014_3p_at

Inferred To

Ctr1A [plasma membrane] (Drosophila melanogaster)

CTR2 [plasma membrane] (Saccharomyces cerevisiae)

SLC31A1 [plasma membrane] (Bos taurus)

SLC31A1 [plasma membrane] (Caenorhabditis elegans)

SLC31A1 [plasma membrane] (Canis familiaris)

SLC31A1 [plasma membrane] (Dictyostelium discoideum)

SLC31A1 [plasma membrane] (Gallus gallus)

SLC31A1 [plasma membrane] (Sus scrofa)

Slc31a1 [plasma membrane] (Mus musculus)

Slc31a1 [plasma membrane] (Rattus norvegicus)

ctr6 [plasma membrane] (Schizosaccharomyces pombe)

slc31a1 [plasma membrane] (Danio rerio)

slc31a1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001850.1

Guide to Pharmacology - Targets

1131

ENSEMBL

ENST00000374212, ENSP00000363329, ENSG00000136868

OpenTargets

ENSG00000136868

GeneCards

SLC31A1

HPA

ENSG00000136868-SLC31A1

PRO

O15431

Pharos - Targets

O15431

GlyGen

O15431

PDB

2LS3, 2LS4, 2LS2

HMDB Protein

HMDBP08240

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15431 SLC31A1	1	SLC31A1 [plasma membrane] (R-HSA-437299)	0.745	6
UniProt:Q6UX71 PXDC2			0.643	3
UniProt:O94766 B3GAT3	2	B3GAT3 R277Q [Golgi membrane] (R-HSA-3621732) B3GAT3 [Golgi membrane] (R-HSA-1889987)	0.643	4
UniProt:Q8NFA0 UBP32			0.643	3
UniProt:O15400 STX7			0.643	5
UniProt:Q6JQN1 ACAD10	1	ACAD10 [mitochondrial matrix] (R-HSA-5695955)	0.527	3
UniProt:Q9H9P8 L2HGDH	1	L2HGDH [mitochondrial inner membrane] (R-HSA-879993)	0.527	3
UniProt:Q96K12 FAR2	1	FAR2 [peroxisomal membrane] (R-HSA-390430)	0.527	2
UniProt:Q6NUM9 RETSAT	1	RETSAT [endoplasmic reticulum membrane] (R-HSA-2980901)	0.527	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.527	2
UniProt:Q16850 CYP51A1	1	CYP51A1 [endoplasmic reticulum membrane] (R-HSA-194721)	0.527	2
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.527	3
UniProt:Q68D85 NCR3LG1	1	NCR3LG1 [plasma membrane] (R-HSA-5683240)	0.527	2
UniProt:Q66K64 DCA15			0.527	2
UniProt:P21860 ERBB3			0.527	2
UniProt:A6NCS6 CB072			0.527	3
UniProt:Q5VWQ8 DAB2IP	1	DAB2IP [cytosol] (R-HSA-5658238)	0.527	2
UniProt:Q9H649 NSUN3			0.527	3
UniProt:Q58EX7 PLEKHG4	1	PLEKHG4 [cytosol] (R-HSA-9679579)	0.527	2
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.527	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	2
UniProt:Q14587 ZNF268	1	ZNF268 [nucleoplasm] (R-HSA-1027427)	0.527	2
UniProt:Q86T26 TM11B			0.527	2
UniProt:Q9Y2I1 NISCH	1	NISCH [cytosol] (R-HSA-9691384)	0.527	2
UniProt:P11117 PPAL			0.527	3
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.527	2
UniProt:Q9BTU6 PI4K2A	1	PI4K2A [cytosol] (R-HSA-1604617)	0.527	2
UniProt:Q8N5C7 DTWD1			0.527	2
UniProt:O15091 PRORP	1	KIAA0391 [mitochondrial matrix] (R-HSA-6785725)	0.527	3
UniProt:O00214 LEG8			0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q9UK61 TASOR	1	TASOR [nucleoplasm] (R-HSA-9844031)	0.527	2
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2

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