Reactome | PIK3CD [cytosol]

PIK3CD [cytosol]

Stable Identifier

R-HSA-1806204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PI3-kinase p110 subunit delta, PK3CD_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00329 PIK3CD

Gene Names

PIK3CD

Chain

chain:1-1044

Reference Genes

BioGPS Gene:5293 PIK3CD

COSMIC (genes):PIK3CD PIK3CD

CTD Gene:5293 PIK3CD

dbSNP Gene:5293 PIK3CD

ENSEMBL:ENSG00000171608 PIK3CD

ENSEMBL_homo_sapiens_GENE:ENSG00000171608.18 PIK3CD

HGNC:8977 PIK3CD

KEGG Gene (Homo sapiens):5293 PIK3CD

Monarch:5293 PIK3CD

NCBI Gene:5293 PIK3CD

OMIM:602839 PIK3CD

UCSC:O00329 PIK3CD

Reference Transcript

Other Identifiers

11719497_at

11751247_a_at

11752018_a_at

11756532_a_at

16658690

203879_PM_at

203879_at

211230_PM_s_at

211230_s_at

2319426

2319434

2319437

2319438

2319439

2319440

2319441

2319442

2319444

2319445

2319446

2319447

2319448

2319449

2319450

2319451

2319452

2319455

2319456

2319457

2319458

2319459

2319460

2319461

2319462

2319464

2319465

2319466

2319467

2319468

2319469

2319470

2319471

2319472

2538968

2539066

32121_at

33627_at

33628_g_at

381_s_at

5293

7897482

A_23_P259833

A_23_P33303

A_24_P71244

A_24_P751082

A_33_P3353941

GE59509

GO:0000166

GO:0001779

GO:0001819

GO:0001938

GO:0002250

GO:0002376

GO:0002551

GO:0002679

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0006468

GO:0006629

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0010595

GO:0010628

GO:0010818

GO:0012501

GO:0014065

GO:0016192

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0023052

GO:0030101

GO:0030154

GO:0030183

GO:0030217

GO:0030335

GO:0030593

GO:0033031

GO:0035004

GO:0035005

GO:0035747

GO:0035754

GO:0036092

GO:0036211

GO:0038089

GO:0042110

GO:0042113

GO:0043303

GO:0043491

GO:0045087

GO:0045766

GO:0046854

GO:0046934

GO:0048015

GO:0048856

GO:0048870

GO:0050852

GO:0050853

GO:0060374

GO:0072672

GO:0098542

GO:1905278

HMNXSV003056415

ILMN_1766275

PH_hs_0025191

PH_hs_0033291

TC01000118.hg

Y10055_at

g2076750_3p_a_at

g2317893_3p_at

Participates

as a component of

Other forms of this molecule

PIK3CD [plasma membrane]

Inferred To

zgc:63473 [cytosol] (Danio rerio)

Pi3K92E [cytosol] (Drosophila melanogaster)

Pik3cd [cytosol] (Mus musculus)

Pik3cd [cytosol] (Rattus norvegicus)

PIK3CD [cytosol] (Bos taurus)

PIK3CD [cytosol] (Canis familiaris)

PIK3CD [cytosol] (Gallus gallus)

PIK3CD [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_006710750.1, NP_005017.3, XP_006710752.1

ZINC - World Drugs

PK3CD_HUMAN

Guide to Pharmacology - Targets

2155

OpenTargets

ENSG00000171608

ZINC - FDA approved

PK3CD_HUMAN

ZINC - Substances

PK3CD_HUMAN

ZINC target

O00329

PRO

O00329

PDB

6PYR, 6G6W, 6OCO, 7JIS, 5DXU, 8BCY, 5T8F, 7LM2, 6PYU, 5M6U, 6OCU, 7LQ1, 5UBT, 5VLR

ZINC - Investigational

PK3CD_HUMAN

IntEnz

2.7.1.137

HPA

ENSG00000171608-PIK3CD

GeneCards

O00329

Ensembl

ENST00000377346, ENSP00000366563, ENSG00000171608, ENST00000698712, ENST00000698713, ENST00000481137, ENSP00000513889, ENSP00000513890, ENSP00000513886

Pharos - Targets

O00329

Orphanet

22804

ZINC - Predictions - Purchasable

PK3CD_HUMAN

HMDB Protein

HMDBP01143

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.851	8

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