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PIK3CD [cytosol]
Stable Identifier
R-HSA-1806204
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3-kinase p110 subunit delta, PK3CD_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
PIK3CA,B,D:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR [plasma membrane] (Homo sapiens)
PIK3CA,B,D:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate (Homo sapiens)
PIK3CA,B,D:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR [plasma membrane] (Homo sapiens)
PIK3CA,B,D:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y-PIK3R1 [cytosol] (Homo sapiens)
p-Y-PIK3R1:PIK3CD [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y-PIK3R1 [cytosol] (Homo sapiens)
p-Y-PIK3R1:PIK3CD [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CA,B,D:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
PIK3CA,B,D:p-Y-PIK3R1 [cytosol] (Homo sapiens)
p-Y-PIK3R1:PIK3CD [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CA,B,D:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PIK3C(1) [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00329 PIK3CD
Gene Names
PIK3CD
Chain
chain:1-1044
Reference Genes
COSMIC (genes):PIK3CD PIK3CD
dbSNP Gene:5293 PIK3CD
ENSEMBL:ENSG00000171608 PIK3CD
Participates
as a component of
p-Y-PIK3R1:PIK3CD [cytosol] (Homo sapiens)
PIK3CD:p-Y464-PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD:PIK3R2 [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
Other forms of this molecule
PIK3CD [plasma membrane]
Inferred To
pik3cd [cytosol]
(Danio rerio)
Pi3K92E [cytosol]
(Drosophila melanogaster)
Pik3cd [cytosol]
(Mus musculus)
Pik3cd [cytosol]
(Rattus norvegicus)
PIK3CD [cytosol]
(Bos taurus)
PIK3CD [cytosol]
(Canis familiaris)
PIK3CD [cytosol]
(Gallus gallus)
PIK3CD [cytosol]
(Sus scrofa)
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.888
9
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