Reactome | RXRA [nucleoplasm]

RXRA [nucleoplasm]

Stable Identifier

R-HSA-381319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Retinoic acid receptor RXR-alpha, RXRA_HUMAN

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - Fatty acid ligands activate PPARA (Homo sapiens)
        
        PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        RXRA [nucleoplasm] (Homo sapiens)
        
        PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
        
        PPARA:RXRA heterodimer [nucleoplasm] (Homo sapiens)
        
        RXRA [nucleoplasm] (Homo sapiens)
  - Heme signaling (Homo sapiens)
    - Expression of NPAS2 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        RXRA [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of RXRA with SUMO1 (Homo sapiens)
        
        RXRA [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        RXRA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19793 RXRA

Gene Names

RXRA, NR2B1

Chain

chain:1-462

Reference Genes

BioGPS Gene:6256 RXRA

COSMIC (genes):RXRA RXRA

CTD Gene:6256 RXRA

dbSNP Gene:6256 RXRA

ENSEMBL:ENSG00000186350 RXRA

ENSEMBL:ENSG00000186350.12 RXRA

HGNC:10477 RXRA

KEGG Gene (Homo sapiens):6256 RXRA

Monarch:6256 RXRA

NCBI Gene:6256 RXRA

OMIM:180245 RXRA

UCSC:P19793 RXRA

Reference Transcript

Other Identifiers

11742843_a_at

11742844_a_at

17090917

202426_PM_s_at

202426_s_at

202449_PM_s_at

202449_s_at

3193370

3193371

3193372

3193390

3193393

3193396

3193399

3193400

3193408

3193410

3193412

3193413

3193414

3193415

3193416

3193418

32800_at

405_at

6256

8159127

A_14_P104460

A_23_P219176

A_23_P423197

GE61154

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001221

GO:0001972

GO:0002157

GO:0003677

GO:0003690

GO:0003700

GO:0003707

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0008270

GO:0008289

GO:0009755

GO:0010875

GO:0016071

GO:0016922

GO:0019899

GO:0023052

GO:0030154

GO:0030501

GO:0032411

GO:0032526

GO:0035357

GO:0042277

GO:0042789

GO:0042802

GO:0042809

GO:0043167

GO:0043226

GO:0043235

GO:0043401

GO:0043565

GO:0044323

GO:0045893

GO:0045944

GO:0046872

GO:0048384

GO:0048856

GO:0050692

GO:0050693

GO:0060089

GO:0070564

GO:0070644

GO:0090575

GO:0140110

GO:1990837

HMNXSV003021752

Hs.20084.0.S1_3p_a_at

ILMN_1687315

PH_hs_0001748

TC09000782.hg

X52773_at

g10862707_3p_a_at

Participates

as an input of

as a component of

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RXRA [cytosol]

p-S21-RXRA [nucleoplasm]

monoSUMO1-K108-RXRA [nucleoplasm]

Inferred To

usp [nucleoplasm] (Drosophila melanogaster)

RXRA [nucleoplasm] (Bos taurus)

RXRA [nucleoplasm] (Canis familiaris)

RXRA [nucleoplasm] (Danio rerio)

RXRA [nucleoplasm] (Gallus gallus)

RXRA [nucleoplasm] (Mus musculus)

RXRA [nucleoplasm] (Rattus norvegicus)

RXRA [nucleoplasm] (Sus scrofa)

rxra [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of RXRA [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001278850.1, NP_002948.1

ZINC - World Drugs

RXRA_HUMAN

Guide to Pharmacology - Targets

610

OpenTargets

ENSG00000186350

ZINC - FDA approved

RXRA_HUMAN

ZINC - Substances

RXRA_HUMAN

ZINC target

P19793

ZINC - Biogenic

RXRA_HUMAN

PRO

P19793

PDB

2P1V, 5ZQU, 2ZXZ, 4M8H, 3E94, 5MKU, 4PP3, 5MK4, 1RXR, 1FBY, 4CN3, 1FM9, 4ZO1, 6HN6, 1BY4, 7B9O, 4CN7, 6A60, 4N5G, 5TBP, 3NSP, 4ZSH, 4M8E, 1K74, 6FBQ, 3FC6, 3R5M, 5EC9, 4RFW, 4CN2, 6XWG, 4J5W, 3DZU, 3FUG, 4N8R, 1MV9, 3DZY, 2NLL, 3R2A, 4RMC, 4PP5, 3OAP, 6LB4, 3H0A, 3E00, 4CN5, 1MVC, 1R0N, 6XWH, 7UW4, 1XLS, 1XVP, 5Z12, 3KWY, 6SJM, 3PCU, 5JI0, 5MKJ, 5MJ5, 4POJ, 4K6I, 1XV9, 7BK4, 7A77, 5LYQ, 4NQA, 1FM6, 3R29, 6A5Y, 7UW2, 1G1U, 1DSZ, 1G5Y, 6LB6, 2P1T, 5UAN, 2P1U, 6A5Z, 2ACL, 1MZN, 4POH, 6STI, 4K4J, 2ZY0, 6JNO, 1YNW, 3NSQ, 6FBR, 7CFO, 5MMW, 6LB5, 4RMD, 4RME, 3FAL, 6JNR, 3OZJ, 7B88, 1RDT, 7NKE, 4OC7, 6L6K, 3UVV, 4J5X

ZINC - Investigational

RXRA_HUMAN

ZINC - Metabolites

RXRA_HUMAN

HPA

ENSG00000186350-RXRA

GeneCards

P19793

Ensembl

ENSP00000419692, ENST00000481739, ENSG00000186350

Pharos - Targets

P19793

ZINC - Predictions - Purchasable

RXRA_HUMAN

HMDB Protein

HMDBP01926

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.951	15
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.857	14
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.791	6
UniProt:Q15596 NCOA2	3	monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) NCOA2 [nucleoplasm] (R-HSA-376398)	0.775	5
UniProt:P37231-1 PPARG			0.715	6
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.697	6
UniProt:P04625	3	polySUMO3-K283,K389-THRA-2 [nucleoplasm] (R-GGA-4719416) monoSUMO1-K283,K389-THRA-2 [nucleoplasm] (R-GGA-4719442) THRA [nucleoplasm] (R-GGA-446180)	0.65	4
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.64	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.625	4
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.609	8
ChEBI:9352 SULINDAC			0.602	3
UniProt:P55055 NR1H2	3	NR1H2 [cytosol] (R-HSA-9619753) polySUMO2,3-K409,K447-NR1H2 [nucleoplasm] (R-HSA-4720435) NR1H2 [nucleoplasm] (R-HSA-375500)	0.592	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.556	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.556	8
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	4
UniProt:P97792-1 CXADR			0.544	2
IntAct:EBI-15743714 COACTIVATOR PEPTIDE			0.544	2
IntAct:EBI-11173936 P2			0.524	4
IntAct:EBI-11173957 P4			0.524	4
IntAct:EBI-11173879 P1			0.524	4
UniProt:Q03463-PRO_0000278730			0.524	3
IntAct:EBI-11173918 IR1			0.524	2
UniProt:Q9JLI4 NCOA6			0.508	2
UniProt:P42224 STAT1	7	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.508	2
IntAct:EBI-10055654 CP2C8			0.499	5
IntAct:EBI-10055663 CP2C8			0.499	5
IntAct:EBI-10055402 PXR-RE			0.499	3

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