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LTK [plasma membrane]
Stable Identifier
R-HSA-9842564
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
fullName evidence="20"Leukocyte tyrosine kinase receptor ecNumber evidence="5 7 14"2.7.10.1/ecNumber, LTK_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by LTK in cancer (Homo sapiens)
CLIP1-LTK fusion autophosphorylates (Homo sapiens)
LTK [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by LTK (Homo sapiens)
Autophosphorylation of LTK dimer:ALKAL1,2 (Homo sapiens)
LTK [plasma membrane] (Homo sapiens)
LTK dimer:ALKAL1,2 [plasma membrane] (Homo sapiens)
LTK [plasma membrane] (Homo sapiens)
LTK binds ALKAL ligand (Homo sapiens)
LTK [plasma membrane] (Homo sapiens)
LTK dimer:ALKAL1,2 [plasma membrane] (Homo sapiens)
LTK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29376 LTK
Gene Names
LTK, TYK1
Chain
signal peptide:1-16, chain:17-864
Reference Genes
BioGPS Gene:4058 LTK
COSMIC (genes):LTK LTK
CTD Gene:4058 LTK
dbSNP Gene:4058 LTK
ENSEMBL:ENSG00000062524 LTK
HGNC:6721 LTK
Monarch:4058 LTK
NCBI Gene:4058 LTK
OMIM:151520 LTK
UCSC:P29376 LTK
Reference Transcript
RefSeq:NM_002344.5 LTK
RefSeq:NM_001135685.1 LTK
RefSeq:NM_206961.3 LTK
Other Identifiers
11741808_a_at
11742069_x_at
1432_s_at
16807627
207106_PM_s_at
207106_s_at
217184_PM_s_at
217184_s_at
32888_at
3619968
3620023
3620024
3620025
3620026
3620027
3620028
3620029
3620030
3620031
3620032
3620034
3620035
3620036
3620037
3620038
3620039
3620040
3620041
3620042
3620043
3620046
3620047
3620048
3620049
3620050
3620051
3620052
3620053
4058
7987650
A_23_P14853
A_33_P3278826
A_33_P3371663
D16105_at
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005886
GO:0006468
GO:0007165
GO:0007169
GO:0008283
GO:0010666
GO:0010976
GO:0016020
GO:0016740
GO:0030298
GO:0038083
GO:0042127
GO:0043066
GO:0043235
GO:0045664
GO:0051897
GO:0060089
GO:0071300
GO:0098772
GO:0140096
HMNXSV003006409
HMNXSV003051443
Hs.210.2.S1_3p_a_at
ILMN_1679290
ILMN_1799871
ILMN_1821743
PH_hs_0020298
TC15001251.hg
X52213_s_at
g4505044_3p_a_at
Participates
as a component of
LTK dimer:ALKAL1,2 [plasma membrane] (Homo sapiens)
as an input of
LTK binds ALKAL ligand (Homo sapiens)
Other forms of this molecule
p-6Y-LTK [plasma membrane]
Inferred To
LTK [plasma membrane]
(Caenorhabditis elegans)
LTK [plasma membrane]
(Danio rerio)
LTK [plasma membrane]
(Drosophila melanogaster)
LTK [plasma membrane]
(Gallus gallus)
LTK [plasma membrane]
(Mus musculus)
LTK [plasma membrane]
(Rattus norvegicus)
LTK [plasma membrane]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
LTK_HUMAN
Guide to Pharmacology - Targets
1838
ENSEMBL
ENSP00000263800
,
ENST00000263800
,
ENSP00000392196
,
ENST00000355166
,
ENST00000453182
,
ENSP00000347293
OpenTargets
ENSG00000062524
ZINC - FDA approved
LTK_HUMAN
ZINC - Substances
LTK_HUMAN
ZINC - Biogenic
LTK_HUMAN
ZINC target
P29376
PRO
P29376
GlyGen
P29376
PDB
7NX1
,
7NX0
ZINC - Investigational
LTK_HUMAN
HPA
ENSG00000062524-LTK
Pharos - Targets
P29376
ZINC - Predictions - Purchasable
LTK_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UXT8 FAM150A
1
ALKAL1 [extracellular region]
(R-HSA-9842576)
0.591
3
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.569
3
UniProt:P29317 EPHA2
2
p-Y588,Y594-EPHA2 [plasma membrane]
(R-HSA-3928380)
EPHA2 [plasma membrane]
(R-HSA-211422)
0.539
3
UniProt:Q9UM73 ALK
20
p-7Y ALK T1087I [plasma membrane]
(R-HSA-9723885)
p-7Y ALK R1061Q [plasma membrane]
(R-HSA-9723884)
p-7Y ALK L1196M [plasma membrane]
(R-HSA-9700464)
p-7Y ALK M1166R [plasma membrane]
(R-HSA-9700477)
p-Y ALK S1206C [plasma membrane]
(R-HSA-9715292)
p- 7Y ALK L1122V [plasma membrane]
(R-HSA-9715294)
p-7Y ALK E1384K [plasma membrane]
(R-HSA-9715285)
p-7Y ALK L1196Q [plasma membrane]
(R-HSA-9700476)
p-7Y ALK V1180L [plasma membrane]
(R-HSA-9715289)
p-7Y ALK G1201R [plasma membrane]
(R-HSA-9701860)
p-7Y ALK I1171T [plasma membrane]
(R-HSA-9700489)
p-7Y ALK R1275L [plasma membrane]
(R-HSA-9699800)
p-7Y ALK F1174C [plasma membrane]
(R-HSA-9699821)
p-7Y ALK F1174V [plasma membrane]
(R-HSA-9699921)
p-7Y ALK M1166N [plasma membrane]
(R-HSA-9723299)
p-7Y ALK M1166T [plasma membrane]
(R-HSA-9700486)
p-7Y ALK Y1239H [plasma membrane]
(R-HSA-9715290)
p-7Y ALK R1275* [plasma membrane]
(R-HSA-9699915)
p-7Y ALK I1171S [plasma membrane]
(R-HSA-9714063)
p-7Y ALK G1128S [plasma membrane]
(R-HSA-9700462)
0.483
2
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