Reactome | LTK [plasma membrane]

LTK [plasma membrane]

Stable Identifier

R-HSA-9842564

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fullName evidence="20"Leukocyte tyrosine kinase receptor ecNumber evidence="5 7 14"2.7.10.1/ecNumber, LTK_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P29376 LTK

Gene Names

LTK, TYK1

Chain

signal peptide:1-16, chain:17-864

Reference Genes

BioGPS Gene:4058 LTK

COSMIC (genes):LTK LTK

CTD Gene:4058 LTK

dbSNP Gene:4058 LTK

ENSEMBL:ENSG00000062524 LTK

HGNC:6721 LTK

Monarch:4058 LTK

NCBI Gene:4058 LTK

OMIM:151520 LTK

UCSC:P29376 LTK

Reference Transcript

Other Identifiers

11741808_a_at

11742069_x_at

1432_s_at

16807627

207106_PM_s_at

207106_s_at

217184_PM_s_at

217184_s_at

32888_at

3619968

3620023

3620024

3620025

3620026

3620027

3620028

3620029

3620030

3620031

3620032

3620034

3620035

3620036

3620037

3620038

3620039

3620040

3620041

3620042

3620043

3620046

3620047

3620048

3620049

3620050

3620051

3620052

3620053

4058

7987650

A_23_P14853

A_33_P3278826

A_33_P3371663

D16105_at

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0007165

GO:0007169

GO:0008283

GO:0010666

GO:0010976

GO:0016020

GO:0016740

GO:0030298

GO:0038083

GO:0042127

GO:0043066

GO:0043235

GO:0045664

GO:0051897

GO:0060089

GO:0071300

GO:0098772

GO:0140096

HMNXSV003006409

HMNXSV003051443

Hs.210.2.S1_3p_a_at

ILMN_1679290

ILMN_1799871

ILMN_1821743

PH_hs_0020298

TC15001251.hg

X52213_s_at

g4505044_3p_a_at

Participates

as a component of

LTK dimer:ALKAL1,2 [plasma membrane] (Homo sapiens)

as an input of

LTK binds ALKAL ligand (Homo sapiens)

Other forms of this molecule

p-6Y-LTK [plasma membrane]

Inferred To

LTK [plasma membrane] (Caenorhabditis elegans)

LTK [plasma membrane] (Danio rerio)

LTK [plasma membrane] (Drosophila melanogaster)

LTK [plasma membrane] (Gallus gallus)

LTK [plasma membrane] (Mus musculus)

LTK [plasma membrane] (Rattus norvegicus)

LTK [plasma membrane] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

LTK_HUMAN

Guide to Pharmacology - Targets

1838

ENSEMBL

ENSP00000263800, ENST00000263800, ENSP00000392196, ENST00000355166, ENST00000453182, ENSP00000347293

OpenTargets

ENSG00000062524

ZINC - FDA approved

LTK_HUMAN

ZINC - Substances

LTK_HUMAN

ZINC - Biogenic

LTK_HUMAN

ZINC target

P29376

PRO

P29376

GlyGen

P29376

PDB

7NX1, 7NX0

ZINC - Investigational

LTK_HUMAN

HPA

ENSG00000062524-LTK

Pharos - Targets

P29376

ZINC - Predictions - Purchasable

LTK_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UXT8 FAM150A	1	ALKAL1 [extracellular region] (R-HSA-9842576)	0.591	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.569	3
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.539	3
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.483	2

Cite Us!