Reactome | p-Y201,Y218-CTLA4 [plasma membrane]

p-Y201,Y218-CTLA4 [plasma membrane]

Stable Identifier

R-HSA-388754

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospho CTLA-4

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Costimulation by the CD28 family (Homo sapiens)
    - CTLA4 inhibitory signaling (Homo sapiens)
      - Phosphorylation of CTLA-4 (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 [plasma membrane] (Homo sapiens)
      - SHP2 phosphatase binds CTLA-4 (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 [plasma membrane] (Homo sapiens)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA-4 dimer [plasma membrane] (Homo sapiens)
        
        p-Y201,Y218-CTLA4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16410 CTLA4

Gene Names

CTLA4, CD152

Chain

signal peptide:1-35, chain:36-223

Reference Genes

BioGPS Gene:1493 CTLA4

COSMIC (genes):CTLA4 CTLA4

CTD Gene:1493 CTLA4

dbSNP Gene:1493 CTLA4

ENSEMBL:ENSG00000163599 CTLA4

ENSEMBL_homo_sapiens_GENE:ENSG00000163599.18 CTLA4

HGNC:2505 CTLA4

KEGG Gene (Homo sapiens):1493 CTLA4

Monarch:1493 CTLA4

NCBI Gene:1493 CTLA4

OMIM:123890 CTLA4

UCSC:P16410 CTLA4

Reference Transcript

Other Identifiers

11730636_a_at

11730637_a_at

11753826_x_at

11753866_x_at

1493

16889819

221331_PM_x_at

221331_x_at

231794_PM_at

231794_at

234362_PM_s_at

234362_s_at

236341_PM_at

236341_at

2523856

2523857

2523858

2523859

2523860

2523861

2523862

8047692

81915_at

A_14_P101727

A_33_P3396139

A_33_P3401556

GE62661

GO:0002250

GO:0002376

GO:0005515

GO:0005794

GO:0005886

GO:0006955

GO:0006974

GO:0007155

GO:0009897

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0030889

GO:0031410

GO:0042129

GO:0042130

GO:0043065

GO:0043226

GO:0045334

GO:0045590

GO:0048471

GO:0048856

GO:0050852

GO:0050853

GO:0098636

HMNXSV003041410

Hs.247824.2.S1_3p_a_at

Hs.313929.0.A1_3p_at

ILMN_1763487

ILMN_2261627

ILMN_2348905

M37245_at

PH_hs_0013114

TC02001201.hg

TC02003774.hg

Participates

as a component of

p-Y201,Y218-CTLA-4 dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

CTLA4 [plasma membrane]

Inferred To

phospho-CTLA4 [plasma membrane] (Bos taurus)

phospho-CTLA4 [plasma membrane] (Gallus gallus)

phospho-CTLA4 [plasma membrane] (Sus scrofa)

phospho-ctla4 [plasma membrane] (Xenopus tropicalis)

phospho-Ctla4 [plasma membrane] (Mus musculus)

phospho-Ctla4 [plasma membrane] (Rattus norvegicus)

phospho-CD152 [plasma membrane] (Canis familiaris)

Modified Residues

Name

O4'-phospho-L-tyrosine at 201

Coordinate

201

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 218

Coordinate

218

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005205.2, NP_001032720.1

Guide to Pharmacology - Targets

2743

OpenTargets

ENSG00000163599

HPA

ENSG00000163599-CTLA4

GeneCards

P16410

Ensembl

ENST00000295854, ENST00000648405, ENSP00000497102, ENSP00000497319, ENSG00000163599, ENST00000487393, ENSP00000295854

PRO

P16410

Pharos - Targets

P16410

Orphanet

15818

PDB

7SU0, 6RP8, 7ELX, 3BX7, 6XY2, 7SU1, 1AH1, 1I85, 2X44, 5GGV, 6RQM, 7CIO, 1I8L, 5TRU, 1H6E, 6RPJ, 7DV4, 8HIT, 3OSK, 5XJ3

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.78	7
UniProt:P42081 CD86	1	CD86 [plasma membrane] (R-HSA-179784)	0.692	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.643	3
UniProt:P50851 LRBA			0.564	2
UniProt:A2RU14 TM218			0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3