monoSUMO1-K108-RXRA [nucleoplasm]

Stable Identifier
R-HSA-4341130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Retinoic acid receptor RXR-alpha, RXRA_HUMAN
monoSUMO1-K108-RXRA [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16912044 Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1

Lee, MH, Chung, SS, Seol, JH, Lee, HW, Baek, SH, Choi, SJ, Bang, OS, Choi, HS, Chung, CH, Rho, EJ

J. Biol. Chem. 2006
External Reference Information
External Reference
Gene Names
RXRA, NR2B1
Chain
chain:1-462
Other Identifiers
11742843_a_at
11742844_a_at
17090917
202426_PM_s_at
202426_s_at
202449_PM_s_at
202449_s_at
3193370
3193371
3193372
3193390
3193393
3193396
3193399
3193400
3193408
3193410
3193412
3193413
3193414
3193415
3193416
3193418
32800_at
405_at
6256
8159127
A_14_P104460
A_23_P219176
A_23_P423197
GE61154
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001221
GO:0001972
GO:0002157
GO:0003677
GO:0003690
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0008270
GO:0008289
GO:0009755
GO:0010875
GO:0016071
GO:0016922
GO:0019899
GO:0023052
GO:0030154
GO:0030501
GO:0032411
GO:0032526
GO:0035357
GO:0042277
GO:0042789
GO:0042802
GO:0042809
GO:0043167
GO:0043226
GO:0043235
GO:0043401
GO:0043565
GO:0044323
GO:0045893
GO:0045944
GO:0046872
GO:0048384
GO:0048856
GO:0050692
GO:0050693
GO:0060089
GO:0070564
GO:0070644
GO:0090575
GO:0140110
GO:1990837
HMNXSV003021752
Hs.20084.0.S1_3p_a_at
ILMN_1687315
PH_hs_0001748
TC09000782.hg
X52773_at
g10862707_3p_a_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 108
Coordinate
108
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
610
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (27)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P10276 RARA  3 0.951 15
 UniProt:Q15788 NCOA1  3 0.857 14
 UniProt:P11473 VDR  2 0.791 6
 UniProt:Q15596 NCOA2  3 0.775 5
 UniProt:P37231-1 PPARG      0.715 6
 UniProt:Q15648 MED1  1 0.697 6
 UniProt:P04625  3 0.65 4
 UniProt:P37231 PPARG  2 0.64 3
 UniProt:Q71SY5 MED25  1 0.625 4
 UniProt:Q13133 NR1H3  1 0.609 8
 ChEBI:9352 SULINDAC      0.602 3
 UniProt:P55055 NR1H2  3 0.592 3
 UniProt:P35637 FUS  1 0.556 3
 UniProt:P27986 PIK3R1  16 0.556 8
 UniProt:O14503 BHLHE40  1 0.556 4
 UniProt:P97792-1 CXADR      0.544 2
 IntAct:EBI-15743714 COACTIVATOR PEPTIDE      0.544 2
 IntAct:EBI-11173936 P2      0.524 4
 IntAct:EBI-11173957 P4      0.524 4
 IntAct:EBI-11173879 P1      0.524 4
 UniProt:Q03463-PRO_0000278730      0.524 3
 IntAct:EBI-11173918 IR1      0.524 2
 UniProt:Q9JLI4 NCOA6      0.508 2
 UniProt:P42224 STAT1  8 0.508 2
 IntAct:EBI-10055654 CP2C8      0.499 5
 IntAct:EBI-10055663 CP2C8      0.499 5
 IntAct:EBI-10055402 PXR-RE      0.499 3
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