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KIR2DL1 [plasma membrane]
Stable Identifier
R-HSA-199538
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Killer cell immunoglobulin-like receptor 2DL1 precursor, K2L1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)
HLA-C group 2 interacting with KIR2DL1 [plasma membrane] (Homo sapiens)
KIR2DL1 [plasma membrane] (Homo sapiens)
KIR2DL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43626 KIR2DL1
Gene Names
KIR2DL1, CD158A, NKAT1
Chain
signal peptide:1-21, chain:22-348
Reference Genes
BioGPS Gene:3802 KIR2DL1
COSMIC (genes):KIR2DL1 KIR2DL1
CTD Gene:3802 KIR2DL1
dbSNP Gene:3802 KIR2DL1
ENSEMBL:ENSG00000125498 KIR2DL1
HGNC:6329 KIR2DL1
Monarch:3802 KIR2DL1
NCBI Gene:3802 KIR2DL1
OMIM:604936 KIR2DL1
UCSC:P43626 KIR2DL1
Reference Transcript
RefSeq:NM_014218.2 KIR2DL1
Other Identifiers
11741900_x_at
11742301_x_at
11761946_at
11761947_x_at
16865484
16876286
208179_PM_x_at
208179_x_at
210890_PM_x_at
210890_x_at
31780_f_at
36886_f_at
36887_f_at
3802
3841708
3841717
3841721
3841723
3841725
3841730
3841731
3841732
3841737
3841740
3841742
3841746
3841749
3841753
3841755
3841757
3841758
3841760
3841763
3841764
3841765
3841766
3841767
3841768
3841769
3841770
3841772
3841773
3841774
3841775
3841776
3841778
3841782
3841785
3841809
3841811
3841814
3841818
3841824
3841829
3841830
3841836
3841837
3841841
3841845
3841846
3841847
3841848
3841851
3841858
4052951
4052958
4052960
4052965
4052968
4052970
4052971
4052973
4052974
4052975
4052976
4052977
4052978
4052992
4052996
4052997
4052998
4052999
4053003
4053005
4053009
4053021
4053022
4053025
4053045
4053046
4053048
4053049
4053050
4053058
4053061
4053063
4053065
4053067
4053068
4053073
4053075
4053079
8031277
8031293
8031297
8031358
8039829
8039842
8039896
A_23_P50571
A_33_P3313920
GO:0002376
GO:0002764
GO:0002769
GO:0005515
GO:0005886
GO:0006955
GO:0016020
GO:0038023
GO:0060089
HMNXSV003004247
HMNXSV003012127
ILMN_1678882
ILMN_1722506
ILMN_1786810
PH_hs_0029293
PH_hs_0030678
PH_hs_0036459
PH_hs_0036998
PH_hs_0038235
PH_hs_0038457
TC19002659.hg
TC19_gl000209_random000006.hg
g1217724_3p_x_at
g2760896_3p_x_at
g897908_3p_x_at
Participates
as a component of
HLA-C group 2 interacting with KIR2DL1 [plasma membrane] (Homo sapiens)
as an input of
KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)
Inferred To
KIR2DL1 [plasma membrane]
(Bos taurus)
KIR2DL1 [plasma membrane]
(Xenopus tropicalis)
KIR3DL2 [plasma membrane]
(Bos taurus)
Homologues of KIR2DL2 [plasma membrane]
(Bos taurus)
Homologues of KIR2DL2 [plasma membrane]
(Mus musculus)
Kir3dl2 [plasma membrane]
(Mus musculus)
KIR2DL4 [plasma membrane]
(Sus scrofa)
KIR2DS1 [plasma membrane]
(Bos taurus)
Homologues of KIR2DL1 [plasma membrane]
(Xenopus tropicalis)
Kir3dl1 [plasma membrane]
(Mus musculus)
Kir3dl1 [plasma membrane]
(Rattus norvegicus)
KIR2DL2 [plasma membrane]
(Bos taurus)
Cross References
OpenTargets
ENSG00000125498
ENSEMBL
ENST00000640308
,
ENST00000619424
,
ENST00000639230
,
ENSP00000336769
,
ENST00000617247
,
ENSP00000478232
,
ENST00000640661
,
ENST00000639616
,
ENST00000640477
,
ENST00000639917
,
ENSP00000482120
,
ENST00000618987
,
ENST00000611594
,
ENSP00000484361
,
ENSP00000480989
,
ENSP00000478263
,
ENSP00000480247
,
ENST00000616302
,
ENST00000612504
,
ENSP00000479644
,
ENSP00000492250
,
ENST00000610627
,
ENSP00000492549
,
ENSP00000478604
,
ENST00000615298
,
ENST00000638780
,
ENST00000640546
,
ENST00000616076
,
ENST00000616310
,
ENSP00000491348
,
ENSP00000491721
,
ENSP00000479363
,
ENSP00000478054
,
ENST00000291633
,
ENST00000620588
,
ENST00000620449
,
ENST00000615920
,
ENST00000622463
,
ENST00000336077
,
ENST00000618507
,
ENSP00000482449
,
ENSP00000482501
,
ENST00000610327
,
ENSP00000491211
,
ENSP00000478633
,
ENST00000611611
,
ENSP00000482506
,
ENSP00000477690
,
ENSP00000491930
,
ENSP00000484559
,
ENST00000618563
,
ENST00000617376
,
ENSP00000483525
,
ENSP00000291633
,
ENSP00000492477
,
ENSP00000478567
,
ENSP00000478202
,
ENSP00000492859
HPA
ENSG00000125498-KIR2DL1
PRO
P43626
Pharos - Targets
P43626
GlyGen
P43626
PDB
1NKR
,
1IM9
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10321 HLA-C
8
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236760)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863915)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]
(R-HSA-1236799)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983354)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]
(R-HSA-983387)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]
(R-HSA-199595)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane]
(R-HSA-6803292)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983044)
0.792
15
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.488
2
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.488
2
UniProt:P29350 PTPN6
5
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.462
4
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