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VEGFR1 [plasma membrane]
Stable Identifier
R-HSA-3004464
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FLT1, Vascular endothelial growth factor receptor 1, VGFR1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
Neurophilin interactions with VEGF and VEGFR (Homo sapiens)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Homo sapiens)
NRP2:VEGFR1 dimer [plasma membrane] (Homo sapiens)
VEGFR1 dimer [plasma membrane] (Homo sapiens)
VEGFR1 [plasma membrane] (Homo sapiens)
VEGFR1 [plasma membrane] (Homo sapiens)
VEGF ligand-receptor interactions (Homo sapiens)
VEGF binds to VEGFR leading to receptor dimerization (Homo sapiens)
VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)
VEGFR1 [plasma membrane] (Homo sapiens)
VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane] (Homo sapiens)
VEGFR1 dimer [plasma membrane] (Homo sapiens)
VEGFR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17948 FLT1
Gene Names
FLT1, FLT, FRT, VEGFR1
Chain
signal peptide:1-26, chain:27-1338
Reference Genes
BioGPS Gene:2321 FLT1
COSMIC (genes):FLT1 FLT1
CTD Gene:2321 FLT1
dbSNP Gene:2321 FLT1
ENSEMBL:ENSG00000102755 FLT1
ENSEMBL_homo_sapiens_GENE:ENSG00000102755.13 FLT1
HGNC:3763 FLT1
KEGG Gene (Homo sapiens):2321 FLT1
Monarch:2321 FLT1
NCBI Gene:2321 FLT1
OMIM:165070 FLT1
UCSC:P17948 FLT1
Reference Transcript
RefSeq:NM_001159920.1 FLT1
RefSeq:NM_001160031.1 FLT1
RefSeq:NM_002019.4 FLT1
RefSeq:NM_001160030.1 FLT1
Other Identifiers
11724970_at
11724971_a_at
11744631_a_at
11746160_a_at
11747162_a_at
1545_g_at
16777715
1963_at
1964_g_at
210287_PM_s_at
210287_s_at
222033_PM_s_at
222033_s_at
226497_PM_s_at
226497_s_at
226498_PM_at
226498_at
2321
2672088
2672091
3507283
3507284
3507285
3507286
3507287
3507288
3507289
3507290
3507292
3507293
3507294
3507295
3507300
3507302
3507305
3507306
3507307
3507308
3507311
3507312
3507322
3507323
3507329
3507330
3507334
3507335
3507336
3507337
3507338
3507339
3507340
3507341
3507342
3507343
3507349
3507352
3507358
3507359
3507360
3507370
3507372
3507374
3507375
3507376
3507377
3507380
3507393
3507394
3507410
3507411
3507412
56189_at
56332_at
7970763
990_at
991_g_at
A_21_P0000024
A_24_P246125
A_24_P42755
A_24_P576191
A_33_P3215883
GE59757
GO:0000166
GO:0001525
GO:0002376
GO:0002548
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005021
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005856
GO:0005886
GO:0005925
GO:0006468
GO:0006935
GO:0007169
GO:0008284
GO:0010863
GO:0015629
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018108
GO:0019838
GO:0023052
GO:0030154
GO:0030335
GO:0031401
GO:0031410
GO:0035924
GO:0036211
GO:0036323
GO:0036332
GO:0038084
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0045766
GO:0045937
GO:0046777
GO:0046872
GO:0048010
GO:0048514
GO:0048584
GO:0048598
GO:0048856
GO:0048870
GO:0051897
GO:0060089
GO:0140096
GO:1905563
GO:1990384
HMNXSV003020372
Hs.138671.2.A1_3p_a_at
Hs.22968.0.S1_3p_a_at
PH_hs_0023904
TC13000517.hg
TC13001387.hg
g451321_3p_s_at
Participates
as an input of
VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Homo sapiens)
as a component of
VEGFR1 dimer [plasma membrane] (Homo sapiens)
Inferred To
VEGFR1 [plasma membrane]
(Bos taurus)
VEGFR1 [plasma membrane]
(Caenorhabditis elegans)
VEGFR1 [plasma membrane]
(Canis familiaris)
VEGFR1 [plasma membrane]
(Drosophila melanogaster)
VEGFR1 [plasma membrane]
(Gallus gallus)
VEGFR1 [plasma membrane]
(Mus musculus)
VEGFR1 [plasma membrane]
(Rattus norvegicus)
VEGFR1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001153392.1
,
NP_002010.2
,
NP_001153503.1
,
NP_001153502.1
ZINC - World Drugs
VGFR1_HUMAN
Guide to Pharmacology - Targets
1812
OpenTargets
ENSG00000102755
ZINC - FDA approved
VGFR1_HUMAN
ZINC - Substances
VGFR1_HUMAN
ZINC target
P17948
ZINC - Biogenic
VGFR1_HUMAN
PRO
P17948
PDB
1RV6
,
1QTY
,
5ABD
,
1QSZ
,
5EX3
,
4CL7
,
1QSV
,
5T89
,
3HNG
,
4CKV
,
1FLT
,
2XAC
ZINC - Investigational
VGFR1_HUMAN
GeneCards
P17948
HPA
ENSG00000102755-FLT1
Ensembl
ENSP00000437631
,
ENST00000615840
,
ENSG00000102755
,
ENST00000541932
,
ENSP00000442630
,
ENST00000539099
,
ENSP00000282397
,
ENSP00000484039
,
ENST00000282397
Pharos - Targets
P17948
ZINC - Predictions - Purchasable
VGFR1_HUMAN
Orphanet
25651
HMDB Protein
HMDBP01462
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15692 VEGFA
2
VEGFA [platelet alpha granule lumen]
(R-HSA-3132764)
VEGFA [extracellular region]
(R-HSA-2975974)
0.819
5
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.623
2
UniProt:P49763 PGF
1
PGF [extracellular region]
(R-HSA-3009042)
0.609
2
UniProt:P15692-4 VEGFA
1
VEGFA-165 [extracellular region]
(R-HSA-4420127)
0.524
3
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.519
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.471
9
UniProt:P01130 LDLR
4
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.463
2
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