Reactome | FASLG(1-281) [extracellular region]

FASLG(1-281) [extracellular region]

Stable Identifier

R-HSA-66212

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FASL, Tumor necrosis factor ligand superfamily member 6 (FAS antigen ligand) (Apoptosis antigen ligand) (APTL) (CD178 antigen), Tumor necrosis factor ligand superfamily member 6, FAS antigen ligand, Apoptosis antigen ligand, APTL, CD178 antigen

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        FASLG (FasL) gene expression (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        FAS-mediated dimerization of procaspase-8 (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FASLG(1-281) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48023 FASLG

Gene Names

FASLG, APT1LG1, CD95L, FASL, TNFSF6

Chain

chain:1-281, chain:1-129, chain:1-81, chain:130-281

Reference Genes

BioGPS Gene:356 FASLG

COSMIC - genes:FASLG FASLG

CTD Gene:356 FASLG

dbSNP Gene:356 FASLG

ENSEMBL:ENSG00000117560 FASLG

HGNC:11936 FASLG

KEGG:hsa:356 FASLG

Monarch:356 FASLG

NCBI Gene:356 FASLG

OMIM:134638 FASLG

UCSC:P48023 FASLG

Reference Transcript

Other Identifiers

11732555_at

11732556_a_at

16673928

1851_s_at

1858_at

210865_PM_at

210865_at

211333_PM_s_at

211333_s_at

2367606

2367607

2367608

2367609

2367610

2367611

2367616

2367617

356

7907430

A_14_P105867

A_23_P369815

A_24_P54220

D38122_at

GE784965

GO:0000122

GO:0002376

GO:0005102

GO:0005123

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005764

GO:0005886

GO:0005901

GO:0006355

GO:0006915

GO:0006925

GO:0006955

GO:0007165

GO:0007267

GO:0008284

GO:0008625

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0016525

GO:0030644

GO:0031410

GO:0032496

GO:0043065

GO:0043123

GO:0043202

GO:0043525

GO:0045742

GO:0046666

GO:0048018

GO:0048388

GO:0048471

GO:0055085

GO:0060205

GO:0061024

GO:0070062

GO:0070231

GO:0070266

GO:0070848

GO:0071346

GO:0097190

GO:0097191

GO:0097527

GO:0098772

GO:1903514

GO:1905782

GO:2000353

GO:2001238

HMNXSV003052998

ILMN_1781824

PH_hs_0000267

TC01001506.hg

U11821_s_at

g12597288_3p_a_at

g601892_3p_at

Participates

as an output of

as an input of

FASL binds FAS Receptor (Homo sapiens)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)

Inferred To

Faslg [extracellular region] (Mus musculus)

Faslg [extracellular region] (Rattus norvegicus)

FASLG [extracellular region] (Bos taurus)

FASLG [extracellular region] (Canis familiaris)

FASLG [extracellular region] (Gallus gallus)

FASLG [extracellular region] (Sus scrofa)

faslg [extracellular region] (Danio rerio)

faslg [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000630.1, NP_001289675.1

ENSEMBL

ENSP00000344739, ENSP00000356694, ENST00000367721, ENST00000340030, ENSG00000117560

OpenTargets

ENSG00000117560

HPA

ENSG00000117560-FASLG

GeneCards

FASLG

PRO

P48023

Pharos - Targets

P48023

GlyGen

P48023

Orphanet

FASLG

PDB

5L36, 4MSV, 5L19

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.802	6
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.792	5
UniProt:Q8WV41 SNX33			0.784	6
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.762	5
UniProt:O76081-6 RGS20			0.718	6
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.697	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.683	4
UniProt:Q8IVL6 P3H3	1	LEPREL2 [endoplasmic reticulum lumen] (R-HSA-1650821)	0.643	3
UniProt:Q8NHP6 MOSPD2	3	MOSPD2 [endosome membrane] (R-HSA-9715095) MOSPD2 [plasma membrane] (R-HSA-6806308) MOSPD2 [specific granule membrane] (R-HSA-6799635)	0.643	3
UniProt:P55345 ANM2			0.643	4
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990) SNX9 [Golgi membrane] (R-HSA-432988)	0.641	3
UniProt:P16333-1 NCK1			0.623	4
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.609	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.591	4
UniProt:Q91ZR2	1	SNX18 [cytosol] (R-MMU-8868038)	0.591	4
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.591	4
UniProt:Q96RU3 FNBP1	1	FNBP1 [cytosol] (R-HSA-8862261)	0.591	4
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.591	4
UniProt:Q9BY11 PACSIN1	1	PACSIN1 [cytosol] (R-HSA-8868269)	0.591	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.571	2
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.571	2
UniProt:Q16610 ECM1	2	ECM1 [extracellular region] (R-HSA-8848909) ECM1 [platelet dense granule lumen] (R-HSA-8848880)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q63HR2 TENS2			0.556	3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7			0.556	3
UniProt:O76081 RGS20	1	RGS20 [plasma membrane] (R-HSA-921136)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.544	3
UniProt:Q9DBG3	5	Ap2b1 [endolysosome membrane] (R-MMU-6784827) Ap2b1 [endocytic vesicle membrane] (R-MMU-416642) Ap2b1 [plasma membrane] (R-MMU-167690) Ap2b1 [clathrin-coated endocytic vesicle membrane] (R-MMU-2130489) Ap2b1 [cytosol] (R-MMU-182166)	0.499	2

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