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NS1 [nucleoplasm]
Stable Identifier
R-FLU-169113
Type
Protein [EntityWithAccessionedSequence]
Species
Influenza A virus
Compartment
nucleoplasm
GO Cellular Component
host cell nucleoplasm
(0044095)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Host mRNA Processing and RNA Silencing (Homo sapiens)
Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)
CPSF:NS1 Complex [nucleoplasm] (Homo sapiens)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)
NS1:PAB II Complex [nucleoplasm] (Homo sapiens)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
Release of NS1 homodimer (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
NS1 homodimer:Importin [nucleoplasm] (Homo sapiens)
NS1 Homodimer [nucleoplasm] (Influenza A virus)
NS1 [nucleoplasm] (Influenza A virus)
External Reference Information
External Reference
UniProt:P03496 NS
Gene Names
NS
Chain
chain:1-230
Reference Genes
BioGPS Gene:956533 NS
KEGG Gene (Hepatitis C Virus):956533 NS
Monarch:956533 NS
NCBI Gene:956533 NS
Reference Transcript
RefSeq:NC_002020.1 NS
Participates
as a component of
NS1 Homodimer [nucleoplasm] (Influenza A virus)
Other forms of this molecule
NS1 [cytosol]
Cross References
RefSeq
NP_040984.1
PRO
P03496
PDB
3O9U
,
5NT1
,
5NT2
,
3O9R
,
3RVC
,
2GX9
,
3O9S
,
3O9T
,
3L4Q
,
3O9Q
,
2ZKO
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95793 STAU1
0.813
6
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.752
13
UniProt:P03496 NS
2
NS1 [nucleoplasm]
(R-FLU-169113)
NS1 [cytosol]
(R-FLU-169118)
0.74
4
UniProt:O75569 PRKRA
2
p-S246,S287-PRKRA [cytosol]
(R-HSA-9834791)
PRKRA [cytosol]
(R-HSA-2399897)
0.667
3
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.659
6
UniProt:P55265 ADAR
2
ADAR [nucleoplasm]
(R-HSA-53939)
ADAR1 [cytosol]
(R-HSA-9835955)
0.655
8
UniProt:Q14258 TRIM25
2
TRIM25 [nucleoplasm]
(R-HSA-5653667)
TRIM25 [cytosol]
(R-HSA-918186)
0.556
3
UniProt:Q15633 TARBP2
2
TARBP2 [cytosol]
(R-HSA-203864)
p-TARBP2 [cytosol]
(R-HSA-9835348)
0.553
2
UniProt:Q9NUL3 STAU2
0.547
2
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.547
3
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.547
2
UniProt:Q9HCE1 MOV10
1
MOV10 [cytosol]
(R-HSA-427772)
0.527
3
UniProt:Q02539 H1-1
1
HIST1H1A [nucleoplasm]
(R-HSA-211245)
0.527
3
UniProt:Q9Y2I1 NISCH
1
NISCH [cytosol]
(R-HSA-9691384)
0.527
6
UniProt:Q9Y3I0 RTCB
1
RTCB [nucleoplasm]
(R-HSA-5696792)
0.527
3
UniProt:Q9NNW5 WDR6
1
WDR6 [cytosol]
(R-HSA-9715165)
0.527
6
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.527
6
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.527
2
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.527
7
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