p-7Y ALK V1180L [plasma membrane]

Stable Identifier
R-HSA-9715289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ALK tyrosine kinase receptor, ALK_HUMAN
Icon
p-7Y ALK V1180L [plasma membrane] icon
p-7Y ALK V1180L [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
25228534 Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

Okuno, Y, Iafrate, AJ, Friboulet, L, Koike, S, Shaw, AT, Engelman, JA, Khan, TM, Lockerman, EL, Takeuchi, K, Taiji, M, Fujita, N, Gainor, JF, Katayama, R

Clin Cancer Res 2014
External Reference Information
External Reference
UniProt:Q9UM73 ALK
Gene Names
ALK
Chain
signal peptide:1-18, chain:19-1620
Reference Genes
BioGPS Gene:238 ALK
COSMIC (genes):ALK ALK
CTD Gene:238 ALK
dbSNP Gene:238 ALK
ENSEMBL:ENSG00000171094 ALK
ENSEMBL_homo_sapiens_GENE:ENSG00000171094.18 ALK
HGNC:427 ALK
KEGG Gene (Homo sapiens):238 ALK
Monarch:238 ALK
NCBI Gene:238 ALK
OMIM:105590 ALK
UCSC:Q9UM73 ALK
Reference Transcript
Other Identifiers
11740853_a_at
11750678_a_at
16896049
208211_PM_s_at
208211_s_at
208212_PM_s_at
208212_s_at
238
2546410
2546411
2546412
2546413
2546414
2546415
2546416
2546417
2546418
2546420
2546423
2546424
2546429
2546431
2546432
2546433
2546434
2546436
2546437
2546439
2546440
2546441
2546442
2546444
2546450
2546458
2546459
2546464
2546468
2546470
2546471
2546472
2546479
2546492
2546493
2546508
2546511
2546512
2546542
2546543
38543_at
451_at
66494_at
8051241
A_23_P10091
A_23_P324304
GE81380
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0007399
GO:0007420
GO:0008201
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0021766
GO:0023052
GO:0030154
GO:0030298
GO:0030534
GO:0032991
GO:0036211
GO:0036269
GO:0038083
GO:0042127
GO:0042802
GO:0042981
GO:0043226
GO:0043235
GO:0045664
GO:0046777
GO:0048666
GO:0048856
GO:0050995
GO:0051092
GO:0060089
GO:0060159
GO:0070062
GO:0090648
GO:0097009
GO:0098772
GO:0140096
GO:1900006
HMNXSV003058035
ILMN_1753135
PH_hs_0024837
TC02001708.hg
U66559_at
g1848243_3p_a_at
Participates
as a component of
Other forms of this molecule
p-7Y ALK T1087I [plasma membrane]
p-7Y ALK R1061Q [plasma membrane]
p-7Y ALK L1196M [plasma membrane]
p-7Y ALK M1166R [plasma membrane]
p-Y ALK S1206C [plasma membrane]
p- 7Y ALK L1122V [plasma membrane]
p-7Y ALK E1384K [plasma membrane]
p-7Y ALK L1196Q [plasma membrane]
p-7Y ALK G1201R [plasma membrane]
p-7Y ALK I1171T [plasma membrane]
p-7Y ALK R1275L [plasma membrane]
p-7Y ALK F1174C [plasma membrane]
p-7Y ALK F1174V [plasma membrane]
p-7Y ALK M1166N [plasma membrane]
p-7Y ALK M1166T [plasma membrane]
p-7Y ALK Y1239H [plasma membrane]
p-7Y ALK R1275* [plasma membrane]
p-7Y ALK I1171S [plasma membrane]
p-7Y ALK G1128S [plasma membrane]
p-7Y ALK G1128V [plasma membrane]
p-7Y ALK H694R [plasma membrane]
p-7Y ALK G881D [plasma membrane]
p-7Y ALK V597A [plasma membrane]
p-7Y ALK S413N [plasma membrane]
ALK H694R [plasma membrane]
ALK del318-782 [plasma membrane]
ALK H224_G318del [plasma membrane]
ALK V597A [plasma membrane]
ALK S413N [plasma membrane]
ALK G881D [plasma membrane]
ALK T1087I [plasma membrane]
ALK K1062M [plasma membrane]
ALK R1061Q [plasma membrane]
ALK G1201E [plasma membrane]
ALK M1166R [plasma membrane]
ALK E1384K [plasma membrane]
ALK R1275* [plasma membrane]
ALK G1201R [plasma membrane]
ALK R1275L [plasma membrane]
ALK M1166N [plasma membrane]
ALK M1166T [plasma membrane]
ALK G1128V [plasma membrane]
ALK G1128S [plasma membrane]
ALK Y1239H [plasma membrane]
ALK F1174S [plasma membrane]
p-7Y ALK del224-318 [plasma membrane]
p-7Y ALK R1275Q [plasma membrane]
p-7Y ALK G1201E [plasma membrane]
p-7Y ALK K1062M [plasma membrane]
p-7Y ALK del318-782 [plasma membrane]
p-7Y ALK L1198F [plasma membrane]
p-7Y ALK R1192P [plasma membrane]
p-7Y ALK F1245C [plasma membrane]
p-7Y ALK G1128A [plasma membrane]
p-7Y ALK F1174S [plasma membrane]
p-7Y ALK I1171N [plasma membrane]
p-7Y ALK F1174L [plasma membrane]
p-7Y ALK F1174I [plasma membrane]
ALK G1128A [plasma membrane]
ALK S1206F [plasma membrane]
ALK T1151dup [plasma membrane]
ALK C1156Y [plasma membrane]
ALK R1192P [plasma membrane]
ALK T1151M [plasma membrane]
ALK L1122V [plasma membrane]
ALK L1152R [plasma membrane]
ALK A1234T [plasma membrane]
ALK D1203N [plasma membrane]
ALK L1198P [plasma membrane]
ALK G1202R [plasma membrane]
ALK I1171S [plasma membrane]
ALK S1206C [plasma membrane]
ALK F1174C [plasma membrane]
ALK I1171N [plasma membrane]
p-7Y-ALK [plasma membrane]
ALK [plasma membrane]
ALK L1196Q [plasma membrane]
ALK G1269S [plasma membrane]
ALK L1196M [plasma membrane]
ALK F1174L [plasma membrane]
ALK R1275Q [plasma membrane]
ALK L1198F [plasma membrane]
ALK S1206Y [plasma membrane]
ALK F1174I [plasma membrane]
ALK V1180L [plasma membrane]
ALK I1171T [plasma membrane]
ALK F1174V [plasma membrane]
ALK G1269A [plasma membrane]
Modified Residues
Name
L-valine 1180 replaced with L-leucine
Coordinate
1180
PsiMod
L-leucine residue [MOD:00020]
A protein modification that effectively converts a source amino acid residue to an L-leucine.
L-valine removal [MOD:01650]
A protein modification that effectively removes or replaces an L-valine.
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
lung squamous cell carcinoma DOID:3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
COSMIC
GeneCards
HPA
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q6UXT8 FAM150A  1 0.655 7
 ChEBI:64310 CRIZOTINIB      0.59 9
 UniProt:P29353 SHC1  5 0.569 3
 ChEBI:62268 CH5424802      0.558 3
 UniProt:Q6UX46 FAM150B  2 0.556 5
 UniProt:P23471 PTPRZ1  2 0.544 2
 UniProt:P08238 HSP90AB1  6 0.524 2
 UniProt:P07949 RET  2 0.499 2
 UniProt:P29317 EPHA2  2 0.483 2
 UniProt:Q9Y2U8 LEMD3  4 0.483 2
 UniProt:P29376 LTK  2 0.483 2
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