Reactome | FGFR1 K656E [plasma membrane]

FGFR1 K656E [plasma membrane]

Stable Identifier

R-HSA-1614373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Literature References

PubMed ID	Title	Journal	Year
10918587	Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN	Oncogene	2000
18772890	Comprehensive genomic characterization defines human glioblastoma genes and core pathways Cancer Genome Atlas Research Network, -	Nature	2008

External Reference Information

External Reference

UniProt:P11362 FGFR1

Gene Names

FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Chain

signal peptide:1-21, chain:22-822

Reference Genes

BioGPS Gene:2260 FGFR1

COSMIC (genes):FGFR1 FGFR1

CTD Gene:2260 FGFR1

dbSNP Gene:2260 FGFR1

ENSEMBL:ENSG00000077782 FGFR1

HGNC:3688 FGFR1

KEGG Gene (Homo sapiens):2260 FGFR1

Monarch:2260 FGFR1

NCBI Gene:2260 FGFR1

OMIM:136350 FGFR1

UCSC:P11362 FGFR1

Reference Transcript

Other Identifiers

0003360142

0005220121

11716548_x_at

11727300_a_at

11727301_a_at

11734765_a_at

11747416_a_at

11747417_x_at

2056_at

2057_g_at

207937_x_at

211535_s_at

2260

226705_at

3132013

3132015

3132017

3132018

3132019

3132020

3132021

3132022

3132023

3132025

3132026

3132027

3132028

3132029

3132031

3132033

3132036

3132039

3132041

3132044

3132046

3132055

3132056

3132070

3132072

3132076

3132078

3132080

3132081

3132083

3132095

3132108

3132109

3132111

3132112

3132113

3132114

3132115

3132116

3493097

36168_at

424_s_at

53212_at

8150318

91005_at

A_23_P301304

A_23_P372923

A_24_P4171

GE59934

GO:0000165

GO:0000166

GO:0001501

GO:0001764

GO:0001837

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0005007

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0007165

GO:0007169

GO:0007275

GO:0008150

GO:0008201

GO:0008219

GO:0008283

GO:0008284

GO:0008543

GO:0009790

GO:0010518

GO:0010863

GO:0014068

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0017134

GO:0018108

GO:0030154

GO:0031410

GO:0032991

GO:0033674

GO:0040011

GO:0042802

GO:0042803

GO:0043009

GO:0043167

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043536

GO:0045595

GO:0045597

GO:0045666

GO:0046777

GO:0048015

GO:0048705

GO:0048856

GO:0048870

GO:0051897

GO:0090722

GO:1905564

GO:2000546

GO:2001239

HMNXSV003006005

HMNXSV003036243

Hs.748.8.A1_3p_at

ILMN_1729369

ILMN_1796229

ILMN_2398261

PH_hs_0000085

X66945_at

g13186246_3p_a_at

g182560_3p_a_at

Participates

as a member of

FGFR1 mutants with enhanced kinase activity [plasma membrane] (Homo sapiens)

as a component of

FGFR1 K656E mutant dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]

FGFR1 N546K [plasma membrane]

FGFR1 R576W [plasma membrane]

p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]

p-8Y-FGFR1 K656E [plasma membrane]

p-8Y-FGFR1 N546K [plasma membrane]

p-8Y- FGFR1 R576W [plasma membrane]

Modified Residues

Name

L-lysine 656 replaced with L-glutamic acid

Coordinate

656

PsiMod

L-glutamic acid residue [MOD:00015]

A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.

L-lysine removal [MOD:01642]

A protein modification that effectively removes or replaces an L-lysine.

Disease

Name	Identifier	Synonyms
glioblastoma	DOID:3068	spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001167536.1, NP_001167537.1, NP_075598.2, NP_001167535.1, NP_001167538.1, NP_075594.1, NP_075593.1, NP_056934.2, NP_001167534.1

ZINC - World Drugs

FGFR1_HUMAN

Guide to Pharmacology - Targets

1808

OpenTargets

ENSG00000077782

ZINC - FDA approved

FGFR1_HUMAN

ZINC - Substances

FGFR1_HUMAN

ZINC - Biogenic

FGFR1_HUMAN

ZINC target

P11362

PRO

P11362

GlyGen

P11362

PDB

5O4A, 2FGI, 5AM7, 3KY2, 1XR0, 6MZQ, 4V01, 5Z0S, 1FGK, 4ZSA, 4RWI, 3KRL, 5ZV2, 6NVL, 6C19, 4NKS, 6P69, 4UWY, 4NKA, 3GQI, 4WUN, 5A4C, 2CR3, 4F65, 6C18, 6ITJ, 3C4F, 3KXX, 3GQL, 5UQ0, 6P68, 3TT0, 3JS2, 5FLF, 1EVT, 3KRJ, 5A46, 1AGW, 1FGI, 4RWK, 1FQ9, 4UWC, 4RWL, 5O49, 5EW8, 6C1C, 5AM6, 3RHX, 4NK9, 5VND, 4F64, 4V05, 4UWB, 3DPK, 1CVS, 4F63, 5W59, 5UR1, 6MZW, 6C1B, 5B7V, 3OJV, 4V04, 4RWJ, 6C1O, 5W21

ZINC - Investigational

FGFR1_HUMAN

COSMIC

COSV58327161

GeneCards

P11362

HPA

ENSG00000077782-FGFR1

Ensembl

ENSP00000432972, ENST00000425967, ENSP00000337247, ENSP00000327229, ENST00000335922, ENSP00000400162, ENSP00000348537, ENSP00000393312, ENST00000484370, ENST00000326324, ENST00000397108, ENSP00000433163, ENSP00000380302, ENST00000397113, ENST00000356207, ENST00000447712, ENSP00000380297, ENSP00000380280, ENSG00000077782, ENST00000532791, ENST00000397091

Pharos - Targets

P11362

ZINC - Predictions - Purchasable

FGFR1_HUMAN

Orphanet

16046

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.871	7
UniProt:P19174 PLCG1	6	p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y-PLCG1 [cytosol] (R-HSA-9029082) PLCG1 [cytosol] (R-HSA-202320) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682)	0.862	9
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.672	26
UniProt:P23352 ANOS1	1	KAL1 [extracellular region] (R-HSA-5654345)	0.626	7
UniProt:P08908 HTR1A	1	HTR1A [plasma membrane] (R-HSA-390971)	0.62	9
UniProt:P10686 Plcg1	8	Plcg1 [cytosol] (R-RNO-202320) p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) Plcg1 [plasma membrane] (R-RNO-182093) p-Plcg1 [plasma membrane] (R-RNO-182042) phospho-Plcg1 [plasma membrane] (R-RNO-167679) Plcg1 [plasma membrane] (R-RNO-167682) phospho-Plcg1 [cytosol] (R-RNO-202357) phospho-Plcg1 [plasma membrane] (R-RNO-1169084)	0.611	4
UniProt:P27986 PIK3R1	15	PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 K459del [plasma membrane] (R-HSA-2399554)	0.569	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:Q9GZV9 FGF23	6	FGF23 [endoplasmic reticulum lumen] (R-HSA-8956697) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633) FGF23(25-251) [extracellular region] (R-HSA-189891) FGF23(25-251) [Golgi lumen] (R-HSA-8851630) p-FGF23 [endoplasmic reticulum lumen] (R-HSA-8957077) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624)	0.544	2
UniProt:P12830 CDH1	10	Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-882) [plasma membrane] (R-HSA-198003) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(751-882) [plasma membrane] (R-HSA-3827962)	0.536	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45P [cytosol] (R-HSA-4791272) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619)	0.536	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.483	2
UniProt:O88900	1	Grb14 [cytosol] (R-RNO-204771)	0.471	3

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