FGFR1 K656E [plasma membrane]

Stable Identifier
R-HSA-1614373
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
FGFR1 K656E [plasma membrane] icon
FGFR1 K656E [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Hart, KC, Robertson, SC, Kanemitsu, MY, Meyer, AN, Tynan, JA, Donoghue, DJ

Oncogene 2000
18772890 Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Cancer Genome Atlas Research, Network

Nature 2008
External Reference Information
External Reference
UniProt:P11362 FGFR1
Gene Names
FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Chain
signal peptide:1-21, chain:22-822
Reference Genes
BioGPS Gene:2260 FGFR1
COSMIC (genes):FGFR1 FGFR1
CTD Gene:2260 FGFR1
dbSNP Gene:2260 FGFR1
ENSEMBL:ENSG00000077782 FGFR1
HGNC:3688 FGFR1
KEGG Gene (Homo sapiens):2260 FGFR1
Monarch:2260 FGFR1
NCBI Gene:2260 FGFR1
OMIM:136350 FGFR1
UCSC:P11362 FGFR1
Reference Transcript
Other Identifiers
0003360142
0005220121
11716548_x_at
11727300_a_at
11727301_a_at
11734765_a_at
11747416_a_at
11747417_x_at
1AGW
1CVS
1EVT
1FGI
1FGK
1FQ9
1XR0
2056_at
2057_g_at
207937_x_at
211535_s_at
2260
226705_at
2CR3
2FGI
3132013
3132015
3132017
3132018
3132019
3132020
3132021
3132022
3132023
3132025
3132026
3132027
3132028
3132029
3132031
3132033
3132036
3132039
3132041
3132044
3132046
3132055
3132056
3132070
3132072
3132076
3132078
3132080
3132081
3132083
3132095
3132108
3132109
3132111
3132112
3132113
3132114
3132115
3132116
33614
3493097
36168_at
3C4F
3DPK
3GQI
3GQL
3JS2
3KRJ
3KRL
3KXX
3KY2
3OJV
3RHX
3TT0
424_s_at
4F63
4F64
4F65
4NK9
4NKA
4NKS
4RWI
4RWJ
4RWK
4RWL
4UWB
4UWC
4UWY
4V01
4V04
4V05
4WUN
4ZSA
53212_at
56402
5A46
5A4C
5AM6
5AM7
5B7V
5EW8
5FLF
5O49
5O4A
5UQ0
5UR1
5VND
5W21
5W59
5Z0S
5ZV2
6C18
6C19
6C1B
6C1C
6C1O
6MZQ
6MZW
76274
8150318
91005_at
A0A0S2Z3Q6
A0A3B3ISD1
A_23_P301304
A_23_P372923
A_24_P4171
AAA35835
AAA35836
AAA35837
AAA35838
AAA35839
AAA35840
AAA35958
AAA35959
AAA35960
AAA75007
AAH15035
AAH18128
AAH91494
AAS79322
AB208919
AC087623
ACO38646
AK222718
AK291754
AK292470
AK309947
ALQ33524
AY585209
B5A958
BAD92156
BAD96438
BAF84443
BAF85159
BC015035
BC018128
BC091494
C1KBH7
C9J1L5
C9J205
CAA36101
CAA37015
CAA40400
CAA40401
CAA40402
CAA40403
CAA40404
CAA47375
CAA68679
CAB033614
CCDS43730
CCDS43731
CCDS43732
CCDS55221
CCDS55222
CCDS55223
CCDS6107
CH471080
E7EU09
E9PKF2
E9PKV7
E9PKX3
E9PN14
E9PNM3
E9PQ40
EAW63305
ENSG00000077782
ENSP00000327229
ENSP00000337247
ENSP00000348537
ENSP00000380280
ENSP00000380297
ENSP00000380302
ENSP00000393312
ENSP00000400162
ENSP00000432972
ENSP00000433163
ENST00000326324
ENST00000326324.10
ENST00000335922
ENST00000335922.9
ENST00000356207
ENST00000356207.9
ENST00000397091
ENST00000397091.9
ENST00000397108
ENST00000397108.8
ENST00000397113
ENST00000397113.6
ENST00000425967
ENST00000425967.7
ENST00000447712
ENST00000447712.6
ENST00000484370
ENST00000484370.5
ENST00000532791
ENST00000532791.5
EntrezGene:2260
EntrezGene:FGFR1
FGFR1
FGFR1-201
FGFR1-202
FGFR1-204
FGFR1-206
FGFR1-208
FGFR1-209
FGFR1-211
FGFR1-214
FGFR1-221
FGFR1-238
FJ809917
g13186246_3p_a_at
g182560_3p_a_at
GE59934
GO:0000122
GO:0000165
GO:0000166
GO:0000278
GO:0001501
GO:0001525
GO:0001657
GO:0001701
GO:0001759
GO:0001764
GO:0002053
GO:0002062
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0007049
GO:0007165
GO:0007169
GO:0007267
GO:0007420
GO:0007435
GO:0007605
GO:0008150
GO:0008201
GO:0008219
GO:0008283
GO:0008284
GO:0008543
GO:0009058
GO:0009790
GO:0010468
GO:0010518
GO:0010629
GO:0010863
GO:0010966
GO:0010976
GO:0014068
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0021700
GO:0021769
GO:0021847
GO:0030154
GO:0030324
GO:0030326
GO:0030901
GO:0031410
GO:0032991
GO:0034641
GO:0035607
GO:0040007
GO:0040011
GO:0042127
GO:0042169
GO:0042472
GO:0042473
GO:0042474
GO:0042802
GO:0042803
GO:0043009
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043536
GO:0043583
GO:0044281
GO:0045595
GO:0045597
GO:0045666
GO:0045787
GO:0046777
GO:0048015
GO:0048339
GO:0048378
GO:0048469
GO:0048514
GO:0048646
GO:0048699
GO:0048705
GO:0048762
GO:0048856
GO:0048870
GO:0050877
GO:0051174
GO:0051301
GO:0051897
GO:0060045
GO:0060117
GO:0060445
GO:0060484
GO:0060665
GO:0070640
GO:0090080
GO:0090272
GO:0090722
GO:1903465
GO:1905564
GO:2000546
GO:2000830
GO:2001239
H0YE20
HGNC:3688
HPA056402
HPA076274
Hs.748.8.A1_3p_at
ILMN_1729369
ILMN_1796229
ILMN_2398261
IPR000719
IPR001245
IPR003598
IPR003599
IPR007110
IPR008266
IPR011009
IPR013098
IPR013151
IPR013783
IPR016248
IPR017441
IPR020635
IPR028174
IPR036179
IPR041159
KU178066
LRG_993
LRG_993t1
M34185
M34186
M34187
M34188
M34641
M37722
M60485
M63887
M63888
M63889
MIM:101600
MIM:123150
MIM:136350
MIM:147950
MIM:166250
MIM:190440
MIM:613001
MIM:615465
NM_001174063
NM_001174064
NM_001174065
NM_001174066
NM_001174067
NM_001354367
NM_001354368
NM_001354369
NM_001354370
NM_015850
NM_023105
NM_023106
NM_023110
NP_001167534
NP_001167535
NP_001167536
NP_001167537
NP_001167538
NP_001341296
NP_001341297
NP_001341298
NP_001341299
NP_056934
NP_075593
NP_075594
NP_075598
PF00047
PF07679
PF07714
PF18123
PH_hs_0000085
PR00109
SM00219
SM00408
SM00409
UPI0000001C0F
UPI000002A994
UPI000002A997
UPI00000534B8
UPI00001618F1
UPI0000167BB6
UPI000153D439
UPI0001CE06A3
X51803
X52833
X57118
X57119
X57120
X57121
X57122
X66945
X66945_at
XM_006716303
XM_006716304
XM_006716307
XM_006716310
XM_006716311
XM_006716312
XM_006716314
XM_011544443
XM_011544444
XM_011544445
XM_011544446
XM_011544447
XM_011544448
XM_011544449
XM_011544450
XM_011544451
XM_017013219
XM_017013220
XM_017013221
XM_017013222
XM_017013224
XM_017013225
XM_017013226
XM_017013227
XM_017013230
XM_024447097
XP_006716366
XP_006716367
XP_006716370
XP_006716373
XP_006716374
XP_006716375
XP_006716377
XP_011542745
XP_011542746
XP_011542747
XP_011542748
XP_011542749
XP_011542750
XP_011542751
XP_011542752
XP_011542753
XP_016868708
XP_016868709
XP_016868710
XP_016868711
XP_016868713
XP_016868714
XP_016868715
XP_016868716
XP_016868719
XP_024302865
XR_001745495
XR_001745496
Y00665
Participant Of
hasMember
hasComponent
Other forms of this molecule
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
FGFR1 N546K [plasma membrane]
FGFR1 R576W [plasma membrane]
p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
p-8Y-FGFR1 K656E [plasma membrane]
p-8Y-FGFR1 N546K [plasma membrane]
p-8Y- FGFR1 R576W [plasma membrane]
Modified Residues
Name
L-lysine 656 replaced with L-glutamic acid
Coordinate
656
PsiMod
L-lysine removal [MOD:01642]
A protein modification that effectively removes or replaces an L-lysine.
L-glutamic acid residue [MOD:00015]
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
glioblastoma 3068 spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
COSMIC
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P19174 PLCG1  6 0.872 9
 UniProt:P09038 FGF2  1 0.801 5
 UniProt:P46934 NEDD4  1 0.672 26
 UniProt:P23352 ANOS1  1 0.626 7
 UniProt:P27986 PIK3R1  15 0.623 5
 UniProt:P10686 Plcg1  8 0.611 4
 UniProt:P35222 CTNNB1  33 0.589 2
 UniProt:P12830 CDH1  10 0.589 3
 UniProt:P46108 CRK  1 0.564 2
 UniProt:Q9GZV9 FGF23  6 0.544 2
 UniProt:O88900  1 0.524 3