Reactome | ICOS [plasma membrane]

ICOS [plasma membrane]

Stable Identifier

R-HSA-9845023

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Inducible T-cell costimulator, ICOS_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)
        
        ICOS dimer [plasma membrane] (Homo sapiens)
        
        ICOS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6W8 ICOS

Gene Names

ICOS, AILIM

Chain

signal peptide:1-20, chain:21-199

Reference Genes

BioGPS Gene:29851 ICOS

COSMIC (genes):ICOS ICOS

CTD Gene:29851 ICOS

dbSNP Gene:29851 ICOS

ENSEMBL:ENSG00000163600 ICOS

HGNC:5351 ICOS

KEGG:hsa:29851 ICOS

Monarch:29851 ICOS

NCBI Gene:29851 ICOS

OMIM:604558 ICOS

UCSC:Q9Y6W8 ICOS

Reference Transcript

RefSeq:NM_012092.4 ICOS

Participates

as a component of

ICOS dimer [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036224.1

Guide to Pharmacology - Targets

2939

ENSEMBL

ENSG00000163600, ENSP00000415951, ENSP00000319476, ENST00000435193, ENST00000316386

OpenTargets

ENSG00000163600

GeneCards

ICOS

HPA

ENSG00000163600-ICOS

PRO

Q9Y6W8

Pharos - Targets

Q9Y6W8

GlyGen

Q9Y6W8

Orphanet

ICOS

PDB

6X4G, 7JOO

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75144 ICOSLG	1	ICOSLG [plasma membrane] (R-HSA-197910)	0.847	10
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.623	5
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.499	5

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