Reactome | NISCH [cytosol]

NISCH [cytosol]

Stable Identifier

R-HSA-9691384

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nischarin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2I1 NISCH

Gene Names

NISCH, IRAS, KIAA0975

Chain

initiator methionine:, chain:2-1504

Reference Genes

BioGPS Gene:11188 NISCH

COSMIC (genes):NISCH NISCH

CTD Gene:11188 NISCH

dbSNP Gene:11188 NISCH

ENSEMBL:ENSG00000010322 NISCH

HGNC:18006 NISCH

Monarch:11188 NISCH

NCBI Gene:11188 NISCH

OMIM:615507 NISCH

UCSC:Q9Y2I1 NISCH

Reference Transcript

Other Identifiers

11188

11716863_a_at

11716864_s_at

11754599_a_at

16941516

201591_PM_s_at

201591_s_at

227392_PM_at

227392_at

2623860

2623861

2623862

2623863

2623864

2623865

2623868

2623869

2623870

2623871

2623874

2623875

2623876

2623877

2623878

2623879

2623880

2623881

2623882

2623883

2623884

2623885

2623886

2623887

2623888

2623889

2623890

2623892

2623893

2623894

2623895

2623896

2623897

2623898

2623900

2623901

2623902

2623903

2623904

2623905

2623906

2623909

2623910

2623911

2623912

2623913

2623914

2623915

2623916

2623917

2623918

33916_at

44768_at

8080320

A_14_P139555

A_23_P41021

A_24_P405621

A_24_P925709

GE55813

GO:0005178

GO:0005515

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005886

GO:0006915

GO:0007010

GO:0008092

GO:0008289

GO:0012501

GO:0015630

GO:0016020

GO:0016601

GO:0030036

GO:0030336

GO:0031410

GO:0035091

GO:0036158

GO:0042802

GO:0043014

GO:0043226

GO:0043231

GO:0045171

GO:0045504

GO:0055037

GO:0065003

HMNXSV003047177

HMNXSV003049816

Hs.285418.0.S1_3p_at

ILMN_1735827

PH_hs_0020406

TC03000335.hg

g6005787_3p_s_at

Participates

as a candidate of

as a member of

RAC1 effectors [cytosol] (Homo sapiens)

Inferred To

Nisch [cytosol] (Mus musculus)

Nisch [cytosol] (Rattus norvegicus)

NISCH [cytosol] (Bos taurus)

NISCH [cytosol] (Canis familiaris)

NISCH [cytosol] (Gallus gallus)

NISCH [cytosol] (Sus scrofa)

Cross References

ZINC - World Drugs

NISCH_HUMAN

ENSEMBL

ENST00000420808, ENSP00000392484, ENSP00000339958, ENST00000345716, ENST00000479054, ENSP00000418232

OpenTargets

ENSG00000010322

ZINC - FDA approved

NISCH_HUMAN

ZINC - Substances

NISCH_HUMAN

ZINC - Biogenic

NISCH_HUMAN

ZINC target

Q9Y2I1

PRO

Q9Y2I1

PDB

8ESF, 3P0C

ZINC - Investigational

NISCH_HUMAN

ZINC - Metabolites

NISCH_HUMAN

HPA

ENSG00000010322-NISCH

Pharos - Targets

Q9Y2I1

ZINC - Predictions - Purchasable

NISCH_HUMAN

HMDB Protein

HMDBP12334

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.527	2
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.527	6
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.508	2