Reactome | p-5Y-NTRK1 [plasma membrane]

p-5Y-NTRK1 [plasma membrane]

Stable Identifier

R-HSA-3009413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-NTRK1, High affinity nerve growth factor receptor, NTRK1_HUMAN, NTRK1

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04629 NTRK1

Gene Names

NTRK1, MTC, TRK, TRKA

Chain

signal peptide:1-32, chain:33-796

Reference Genes

BioGPS Gene:4914 NTRK1

COSMIC (genes):NTRK1 NTRK1

CTD Gene:4914 NTRK1

dbSNP Gene:4914 NTRK1

ENSEMBL:ENSG00000198400 NTRK1

ENSEMBL_homo_sapiens_GENE:ENSG00000198400 NTRK1

HGNC:8031 NTRK1

KEGG Gene (Homo sapiens):4914 NTRK1

Monarch:4914 NTRK1

NCBI Gene:4914 NTRK1

OMIM:191315 NTRK1

UCSC:P04629 NTRK1

Reference Transcript

Other Identifiers

0000130093

11741674_a_at

16672186

1892_s_at

1HE7

1SHC

1WWA

1WWW

208605_s_at

2361762

2361765

2361767

2361768

2361769

2361770

2361771

2361773

2361774

2361775

2361776

2361777

2361778

2361779

2361781

2361783

2361784

2361785

2361787

2361789

2361790

2IFG

2N90

35799

36805_s_at

4606

4914

4AOJ

4CRP

4F0I

4GT5

4PMM

4PMP

4PMS

4PMT

4YNE

4YPS

5H3Q

5I8A

5JFS

5JFV

5JFW

5JFX

5KMI

5KMJ

5KMK

5KML

5KMM

5KMN

5KMO

5KVT

5WR7

6D1Y

6D1Z

6D20

76570

7906244

A_23_P34804

A_24_P265506

AAA36770

AAH62580

AAI36555

AAI44240

AAP88292

AB019488

AHW56542

AK312704

AL158169

AY321513

BAA34355

BAG35582

BC062580

BC136554

BC144239

CAA27243

CAA29888

CAA44719

CAA59936

CAB004606

CCDS1161

CCDS30890

CCDS30891

DB265639

E9PQG0

ENSG00000198400

ENSP00000357179

ENSP00000376120

ENSP00000431418

ENST00000368196

ENST00000392302

ENST00000524377

EntrezGene:4914

g4585711_3p_a_at

GE57874

GO:0000003

GO:0000139

GO:0000166

GO:0000186

GO:0000902

GO:0001934

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0005004

GO:0005030

GO:0005166

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005794

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0007169

GO:0007267

GO:0007275

GO:0007399

GO:0007411

GO:0007568

GO:0007611

GO:0007623

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0009314

GO:0009986

GO:0010008

GO:0010465

GO:0010623

GO:0010976

GO:0014068

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019233

GO:0019899

GO:0019900

GO:0021553

GO:0022607

GO:0030154

GO:0030183

GO:0030424

GO:0030425

GO:0031410

GO:0031667

GO:0031901

GO:0031902

GO:0032991

GO:0034641

GO:0035094

GO:0038083

GO:0038179

GO:0038180

GO:0040011

GO:0042490

GO:0042493

GO:0042803

GO:0043025

GO:0043066

GO:0043068

GO:0043121

GO:0043167

GO:0043226

GO:0043235

GO:0043408

GO:0043410

GO:0043524

GO:0043547

GO:0046579

GO:0046777

GO:0048011

GO:0048013

GO:0048015

GO:0048406

GO:0048485

GO:0048678

GO:0048856

GO:0050877

GO:0050965

GO:0050966

GO:0051092

GO:0051599

GO:0051602

GO:0051965

GO:0051968

GO:0055037

GO:0060009

GO:0060384

GO:0060385

GO:0061368

GO:0070374

GO:0071316

GO:0071363

GO:1901215

GO:1990090

HGNC:8031

HPA035799

HPA076570

ILMN_1731777

ILMN_1770307

ILMN_2326075

IPR000483

IPR000719

IPR001245

IPR001611

IPR002011

IPR007110

IPR008266

IPR011009

IPR013783

IPR017441

IPR020461

IPR020635

IPR020777

IPR031635

IPR032675

IPR036179

J3KP20

KJ534902

LRG_261

M23102

MIM:155240

MIM:191315

MIM:256800

NM_001007792

NM_001012331

NM_002529

NP_001007793

NP_001012331

NP_002520

NTRK1

NTRK1-202

NTRK1-203

NTRK1-206

PF07714

PF13855

PF16920

PH_hs_0019265

PR00109

PR01939

PR01940

SM00082

SM00219

TC01001328.hg

uc001fqf.2

uc001fqh.2

uc001fqi.2

UPI000013D5D3

UPI0000204AA8

UPI00003665B8

X03541

X06704

X5DR71

X62947

X85960

Participant Of

hasComponent

Other forms of this molecule

p-5Y-NTRK1 [Golgi membrane]

NTRK1 [Golgi membrane]

NTRK1 [plasma membrane]

Inferred To

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Caenorhabditis elegans)

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Dictyostelium discoideum)

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Drosophila melanogaster)

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Gallus gallus)

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Saccharomyces cerevisiae)

Ghost homologue of p-5Y-NTRK1 [plasma membrane] (Schizosaccharomyces pombe)

phospho-p-5Y-NTRK1 [plasma membrane] (Bos taurus)

phospho-p-5Y-NTRK1 [plasma membrane] (Canis familiaris)

phospho-p-5Y-NTRK1 [plasma membrane] (Danio rerio)

phospho-p-5Y-NTRK1 [plasma membrane] (Mus musculus)

phospho-p-5Y-NTRK1 [plasma membrane] (Rattus norvegicus)

phospho-p-5Y-NTRK1 [plasma membrane] (Sus scrofa)

phospho-p-5Y-NTRK1 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 490

Coordinate

490

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 670

Coordinate

670

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 674

Coordinate

674

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 675

Coordinate

675

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 785

Coordinate

785

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001012331.1, NP_002520.2, NP_001007793.1

ZINC - World Drugs

NTRK1_HUMAN

OpenTargets

ENSG00000198400

ZINC - FDA approved

NTRK1_HUMAN

GeneCards

P04629

ZINC - Substances

NTRK1_HUMAN

ZINC target

P04629

PRO

P04629

BRENDA (Homo sapiens)

2.7.10.1

Orphanet

16581

ZINC - Predictions - Purchasable

NTRK1_HUMAN

PDB

5JFX, 4PMS, 6DKI, 5KML, 4GT5, 5KMK, 6D22, 1WWA, 4CRP, 5I8A, 2N90, 4PMT, 5JFS, 5KMM, 4AOJ, 4YPS, 4PMM, 5JFV, 1SHC, 5H3Q, 1HE7, 6DKW, 5KMN, 6DKB, 1WWW, 2IFG, 6D1Y, 5KMI, 5WR7, 5KVT, 4F0I, 4PMP, 5JFW, 6DKG, 5KMO, 6D20, 5KMJ, 4YNE, 6D1Z

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01138 NGF	7	NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF [extracellular region] (R-HSA-167034) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF [Golgi lumen] (R-HSA-166515) NGF(19-241) [extracellular region] (R-HSA-187033) NGF [cytosol] (R-HSA-190059)	0.683	3
UniProt:P01138-PRO_0000019600 NGF			0.544	2
UniProt:Q8K4V6 Q8K4V6			0.524	2
UniProt:O75385 ULK1	7	ULK1 [mitochondrial outer membrane] (R-HSA-8948145) ULK1 [cytosol] (R-HSA-1632847) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [recycling endosome] (R-HSA-8854761)	0.499	2
UniProt:Q13501 SQSTM1	2	SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.499	2
UniProt:P04629 NTRK1	4	NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.488	2
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.463	3
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.462	2
UniProt:P19174 PLCG1	6	PLCG1 [plasma membrane] (R-HSA-167682) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.462	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.462	2