Reactome | p-S271,T275-MAP2K7 [cytosol]

p-S271,T275-MAP2K7 [cytosol]

Stable Identifier

R-HSA-450353

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S271,T275-MKK7, MAP kinase kinase 7(phosphorylated), MAP2K7

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External Reference Information

External Reference

UniProt:O14733 MAP2K7

Gene Names

MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

Chain

initiator methionine:, chain:2-419

Reference Genes

BioGPS Gene:5609 MAP2K7

COSMIC (genes):MAP2K7 MAP2K7

CTD Gene:5609 MAP2K7

dbSNP Gene:5609 MAP2K7

ENSEMBL:ENSG00000076984 MAP2K7

HGNC:6847 MAP2K7

KEGG:hsa:5609 MAP2K7

Monarch:5609 MAP2K7

NCBI Gene:5609 MAP2K7

OMIM:603014 MAP2K7

UCSC:O14733 MAP2K7

Reference Transcript

Participates

as an output of

Phosphorylation of MEK7 by MEKK1 (Homo sapiens)

as a member of

p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)

Other forms of this molecule

MAP2K7 [cytosol]

MAP2K7(2-?) [cytosol]

MAP2K7(?-419) [cytosol]

Inferred To

phospho-MAP2K7 [cytosol] (Canis familiaris)

phospho-p-S271,T275-MAP2K7 [cytosol] (Dictyostelium discoideum)

phospho-p-S271,T275-MAP2K7 [cytosol] (Mus musculus)

phospho-p-S271,T275-MAP2K7 [cytosol] (Rattus norvegicus)

phospho-map2k7 [cytosol] (Danio rerio)

Modified Residues

Name

O-phospho-L-serine at 271

Coordinate

271

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 275

Coordinate

275

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001284485.1, NP_001284484.1, NP_660186.1

Guide to Pharmacology - Targets

2068

OpenTargets

ENSG00000076984

ENSEMBL

ENST00000397979, ENSG00000076984, ENSP00000381068, ENST00000397983, ENSP00000381066, ENST00000397981, ENSP00000381070

ZINC - FDA approved

MP2K7_HUMAN

ZINC - Substances

MP2K7_HUMAN

ZINC - Biogenic

MP2K7_HUMAN

ZINC target

O14733

PRO

O14733

PDB

3WZU, 7OVK, 6YG2, 6QFR, 6YG3, 5B2K, 5B2L, 6QHR, 7OVL, 6YZ4, 6IB2, 7OVM, 6YFZ, 7OVJ, 6QHO, 6YG6, 5B2M, 6IB0, 6YG0, 7CBX, 6YG1, 4UX9, 7OVN, 7OVI, 6QFL, 5Y8U, 2DYL, 5Z1E, 5Z1D, 6QG7, 6YG7, 6QFT, 6QG4, 6YG4, 6YG5, 5Y90

ZINC - Investigational

MP2K7_HUMAN

IntEnz

2.7.12.2

HPA

ENSG00000076984-MAP2K7

GeneCards

MAP2K7

Pharos - Targets

O14733

ZINC - Predictions - Purchasable

MP2K7_HUMAN

HMDB Protein

HMDBP08761

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [endosome membrane] (R-HSA-450315) p-T187-MAP3K7 [cytosol] (R-HSA-206014) p-MAP3K7 [cytosol] (R-HSA-168163) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968)	0.674	3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE			0.672	7
UniProt:O75293 GA45B			0.645	8
UniProt:Q9UQF2 JIP1			0.623	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.483	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.462	3