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p-S271,T275-MAP2K7 [cytosol]
Stable Identifier
R-HSA-450353
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S271,T275-MKK7, MAP kinase kinase 7(phosphorylated), MAP2K7
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14733 MAP2K7
Gene Names
MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
Chain
initiator methionine:, chain:2-419
Reference Genes
BioGPS Gene:5609 MAP2K7
COSMIC (genes):MAP2K7 MAP2K7
CTD Gene:5609 MAP2K7
dbSNP Gene:5609 MAP2K7
ENSEMBL:ENSG00000076984 MAP2K7
HGNC:6847 MAP2K7
KEGG:hsa:5609 MAP2K7
Monarch:5609 MAP2K7
NCBI Gene:5609 MAP2K7
OMIM:603014 MAP2K7
UCSC:O14733 MAP2K7
Reference Transcript
RefSeq:NM_001297555.1 MAP2K7
RefSeq:NM_145185.3 MAP2K7
RefSeq:NM_001297556.1 MAP2K7
Participates
as an output of
Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
as a member of
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
Other forms of this molecule
MAP2K7 [cytosol]
MAP2K7(2-?) [cytosol]
MAP2K7(?-419) [cytosol]
Inferred To
phospho-MAP2K7 [cytosol]
(Canis familiaris)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Dictyostelium discoideum)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Mus musculus)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Rattus norvegicus)
phospho-map2k7 [cytosol]
(Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 271
Coordinate
271
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 275
Coordinate
275
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001284485.1
,
NP_001284484.1
,
NP_660186.1
Guide to Pharmacology - Targets
2068
OpenTargets
ENSG00000076984
ENSEMBL
ENST00000397979
,
ENSG00000076984
,
ENSP00000381068
,
ENST00000397983
,
ENSP00000381066
,
ENST00000397981
,
ENSP00000381070
ZINC - FDA approved
MP2K7_HUMAN
ZINC - Substances
MP2K7_HUMAN
ZINC - Biogenic
MP2K7_HUMAN
ZINC target
O14733
PRO
O14733
PDB
3WZU
,
7OVK
,
6YG2
,
6QFR
,
6YG3
,
5B2K
,
5B2L
,
6QHR
,
7OVL
,
6YZ4
,
6IB2
,
7OVM
,
6YFZ
,
7OVJ
,
6QHO
,
6YG6
,
5B2M
,
6IB0
,
6YG0
,
7CBX
,
6YG1
,
4UX9
,
7OVN
,
7OVI
,
6QFL
,
5Y8U
,
2DYL
,
5Z1E
,
5Z1D
,
6QG7
,
6YG7
,
6QFT
,
6QG4
,
6YG4
,
6YG5
,
5Y90
ZINC - Investigational
MP2K7_HUMAN
IntEnz
2.7.12.2
HPA
ENSG00000076984-MAP2K7
GeneCards
MAP2K7
Pharos - Targets
O14733
ZINC - Predictions - Purchasable
MP2K7_HUMAN
HMDB Protein
HMDBP08761
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43318 MAP3K7
10
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
p-MAP3K7 [cytosol]
(R-HSA-168163)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
0.674
3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE
0.672
7
UniProt:O75293 GA45B
0.645
8
UniProt:Q9UQF2 JIP1
0.623
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.564
2
UniProt:P45983 MAPK8
3
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
MAPK8 [cytosol]
(R-HSA-168141)
0.483
4
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.462
3
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