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p-S271,T275-MAP2K7 [cytosol]
Stable Identifier
R-HSA-450353
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S271,T275-MKK7, MAP kinase kinase 7(phosphorylated), MAP2K7
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
p-S271,T275-MAP2K7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14733 MAP2K7
Gene Names
MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
Chain
initiator methionine:1, chain:2-419
Reference Genes
BioGPS Gene:5609 MAP2K7
COSMIC (genes):MAP2K7 MAP2K7
CTD Gene:5609 MAP2K7
dbSNP Gene:5609 MAP2K7
ENSEMBL:ENSG00000076984.18 MAP2K7
HGNC:6847 MAP2K7
KEGG Gene (Homo sapiens):5609 MAP2K7
Monarch:5609 MAP2K7
NCBI Gene:5609 MAP2K7
OMIM:603014 MAP2K7
UCSC:O14733 MAP2K7
Reference Transcript
RefSeq:NM_001297555.1 MAP2K7
RefSeq:NM_145185.3 MAP2K7
RefSeq:NM_001297556.1 MAP2K7
Other Identifiers
11723595_s_at
11723596_a_at
11723597_at
11723598_x_at
11752702_a_at
16857799
209951_PM_s_at
209951_s_at
209952_PM_s_at
209952_s_at
226023_PM_at
226023_at
226053_PM_at
226053_at
3819264
3819265
3819266
3819274
3819275
3819277
3819279
3819281
3819283
3819285
3819286
3819287
3819288
3819289
3819290
3819291
3819292
3819293
3819294
3819295
3819296
3819297
41444_at
5609
59996_at
8025351
A_23_P78628
A_33_P3236651
GE785894
GO:0000165
GO:0000166
GO:0000287
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006970
GO:0007165
GO:0007254
GO:0008022
GO:0008545
GO:0009408
GO:0009411
GO:0009611
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019903
GO:0023052
GO:0031435
GO:0032200
GO:0032212
GO:0034612
GO:0036211
GO:0038095
GO:0043226
GO:0043507
GO:0043525
GO:0045893
GO:0046330
GO:0046872
GO:0051403
GO:0051973
GO:0070374
GO:0071222
GO:0071347
GO:0071470
GO:0072709
GO:0090398
GO:0098772
GO:0106310
GO:0140096
GO:0140677
GO:1904355
GO:2000671
HMNXSV003016511
HMNXSV003058459
Hs.110299.0.A1_3p_a_at
Hs.296234.0.A1_3p_at
Hs.296234.0.A2_3p_at
ILMN_1781104
PH_hs_0006079
TC19000140.hg
g2811125_3p_a_at
Participates
as an output of
Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
as a member of
p-MAP2K4/p-MAP2K7 [cytosol] (Homo sapiens)
Other forms of this molecule
MAP2K7(?-419) [cytosol]
MAP2K7(2-?) [cytosol]
MAP2K7 [cytosol]
Inferred To
phospho-MAP2K7 [cytosol]
(Sus scrofa)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Canis familiaris)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Danio rerio)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Dictyostelium discoideum)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Mus musculus)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Rattus norvegicus)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S271,T275-MAP2K7 [cytosol]
(Schizosaccharomyces pombe)
Homologues of p-S271,T275-MAP2K7 [cytosol]
(Saccharomyces cerevisiae)
Homologues of p-S271,T275-MAP2K7 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 271
Coordinate
271
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 275
Coordinate
275
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001284484.1
,
NP_660186.1
,
NP_001284485.1
ZINC - World Drugs
MP2K7_HUMAN
Guide to Pharmacology - Targets
2068
OpenTargets
ENSG00000076984
ZINC - FDA approved
MP2K7_HUMAN
ZINC - Substances
MP2K7_HUMAN
ZINC - Biogenic
MP2K7_HUMAN
ZINC target
O14733
PRO
O14733
PDB
7OVM
,
5Z1E
,
6YG2
,
6YG4
,
7OVL
,
6QFR
,
6YG3
,
6YFZ
,
5B2L
,
6YZ4
,
7OVK
,
6YG0
,
7CBX
,
2DYL
,
5Z1D
,
6QFL
,
7OVJ
,
6YG1
,
5B2M
,
6YG7
,
7OVI
,
4UX9
,
5B2K
,
6QHO
,
6QG4
,
6YG5
,
6QFT
,
6IB0
,
6QG7
,
7OVN
,
6QHR
,
6YG6
,
5Y90
,
5Y8U
,
3WZU
,
6IB2
ZINC - Investigational
MP2K7_HUMAN
IntEnz
2.7.12.2
HPA
ENSG00000076984-MAP2K7
GeneCards
O14733
Ensembl
ENSG00000076984
,
ENSP00000381066
,
ENSP00000381068
,
ENST00000397983
,
ENST00000397981
,
ENST00000397979
,
ENSP00000381070
Pharos - Targets
O14733
ZINC - Predictions - Purchasable
MP2K7_HUMAN
HMDB Protein
HMDBP08761
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.674
3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE
0.672
7
UniProt:O75293 GA45B
0.645
8
UniProt:Q9UQF2 JIP1
0.623
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.483
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
3
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