Reactome | PIK3CD [plasma membrane]

PIK3CD [plasma membrane]

Stable Identifier

R-HSA-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PI3-kinase p110 subunit delta, PK3CD_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - RET signaling (Homo sapiens)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
      - CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
      - p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
      - p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - 14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
      - Regulation of signaling by CBL (Homo sapiens)
        
        CBL is tyrosine phosphorylated (Homo sapiens)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CBL ubiquitinates PI3K (Homo sapiens)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K delta [cytosol] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        BCAP Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
        
        PIK3CD [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00329 PIK3CD

Gene Names

PIK3CD

Chain

chain:1-1044

Reference Genes

BioGPS Gene:5293 PIK3CD

COSMIC (genes):PIK3CD PIK3CD

CTD Gene:5293 PIK3CD

dbSNP Gene:5293 PIK3CD

ENSEMBL:ENSG00000171608 PIK3CD

ENSEMBL_homo_sapiens_GENE:ENSG00000171608.18 PIK3CD

HGNC:8977 PIK3CD

KEGG Gene (Homo sapiens):5293 PIK3CD

Monarch:5293 PIK3CD

NCBI Gene:5293 PIK3CD

OMIM:602839 PIK3CD

UCSC:O00329 PIK3CD

Reference Transcript

Other Identifiers

11719497_at

11751247_a_at

11752018_a_at

11756532_a_at

16658690

203879_PM_at

203879_at

211230_PM_s_at

211230_s_at

2319426

2319434

2319437

2319438

2319439

2319440

2319441

2319442

2319444

2319445

2319446

2319447

2319448

2319449

2319450

2319451

2319452

2319455

2319456

2319457

2319458

2319459

2319460

2319461

2319462

2319464

2319465

2319466

2319467

2319468

2319469

2319470

2319471

2319472

2538968

2539066

32121_at

33627_at

33628_g_at

381_s_at

5293

7897482

A_23_P259833

A_23_P33303

A_24_P71244

A_24_P751082

A_33_P3353941

GE59509

GO:0000166

GO:0001779

GO:0001819

GO:0001938

GO:0002250

GO:0002376

GO:0002551

GO:0002679

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0006468

GO:0006629

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0010595

GO:0010628

GO:0010818

GO:0012501

GO:0016192

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0023052

GO:0030101

GO:0030154

GO:0030183

GO:0030217

GO:0030335

GO:0030593

GO:0033031

GO:0035005

GO:0035747

GO:0035754

GO:0036092

GO:0036211

GO:0038089

GO:0042110

GO:0042113

GO:0043303

GO:0043491

GO:0045087

GO:0045766

GO:0046854

GO:0046934

GO:0048015

GO:0048856

GO:0048870

GO:0050852

GO:0050853

GO:0060374

GO:0072672

GO:0098542

GO:1905278

HMNXSV003056415

ILMN_1766275

PH_hs_0025191

PH_hs_0033291

TC01000118.hg

Y10055_at

g2076750_3p_a_at

g2317893_3p_at

Participates

as a component of

Other forms of this molecule

PIK3CD [cytosol]

Inferred To

Pi3K92E [plasma membrane] (Drosophila melanogaster)

Pik3cd [plasma membrane] (Mus musculus)

Pik3cd [plasma membrane] (Rattus norvegicus)

PIK3CD [plasma membrane] (Bos taurus)

PIK3CD [plasma membrane] (Canis familiaris)

PIK3CD [plasma membrane] (Gallus gallus)

PIK3CD [plasma membrane] (Sus scrofa)

pik3cd [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_005017.3, XP_006710752.1, XP_006710750.1

ZINC - World Drugs

PK3CD_HUMAN

Guide to Pharmacology - Targets

2155

OpenTargets

ENSG00000171608

ZINC - FDA approved

PK3CD_HUMAN

ZINC - Substances

PK3CD_HUMAN

ZINC target

O00329

PRO

O00329

PDB

6OCO, 5DXU, 6PYR, 7LQ1, 6PYU, 6G6W, 6OCU, 8BCY, 5T8F, 5M6U, 7LM2, 5UBT, 5VLR, 7JIS

ZINC - Investigational

PK3CD_HUMAN

IntEnz

2.7.1.137

HPA

ENSG00000171608-PIK3CD

GeneCards

O00329

Ensembl

ENSG00000171608, ENSP00000513890, ENSP00000513889, ENSP00000513886, ENSP00000366563, ENST00000698712, ENST00000698713, ENST00000377346, ENST00000481137

Pharos - Targets

O00329

ZINC - Predictions - Purchasable

PK3CD_HUMAN

Orphanet

22804

HMDB Protein

HMDBP01143

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.888	9

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