Reactome | EPHA1 [plasma membrane]

EPHA1 [plasma membrane]

Stable Identifier

R-HSA-211415

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EphA1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21709 EPHA1

Gene Names

EPHA1, EPH, EPHT, EPHT1

Chain

signal peptide:1-25, chain:26-976

Reference Genes

BioGPS Gene:2041 EPHA1

COSMIC (genes):EPHA1 EPHA1

CTD Gene:2041 EPHA1

dbSNP Gene:2041 EPHA1

ENSEMBL:ENSG00000146904 EPHA1

ENSEMBL_homo_sapiens_GENE:ENSG00000146904.9 EPHA1

ENSEMBL_homo_sapiens_GENE:ENSG00000284816.2 EPHA1

HGNC:3385 EPHA1

KEGG Gene (Homo sapiens):2041 EPHA1

Monarch:2041 EPHA1

NCBI Gene:2041 EPHA1

OMIM:179610 EPHA1

UCSC:P21709 EPHA1

Reference Transcript

RefSeq:NM_005232.4 EPHA1

Other Identifiers

1108_s_at

11723373_a_at

11751296_a_at

17063948

2041

205977_PM_s_at

205977_s_at

3077323

3077324

3077325

3077326

3077328

3077329

3077330

3077331

3077333

3077334

3077337

3077340

3077343

3077344

3077345

3077346

3077347

3077348

3077349

3077350

3077351

3077355

3077357

3077360

3077361

8143575

A_23_P157333

GE62812

GO:0000166

GO:0001525

GO:0001954

GO:0001968

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005005

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0006469

GO:0007010

GO:0007155

GO:0007166

GO:0007169

GO:0008284

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019901

GO:0023052

GO:0030335

GO:0030336

GO:0034446

GO:0036211

GO:0043087

GO:0043235

GO:0045766

GO:0046777

GO:0048013

GO:0048856

GO:0048870

GO:0051496

GO:0060089

GO:0090630

GO:0140096

HMNXSV003006546

ILMN_1664265

M18391_s_at

PH_hs_0005023

TC07001971.hg

g4885208_3p_a_at

Participates

as a member of

EPHAs [plasma membrane] (Homo sapiens)

as an output of

Expression of EPHA1 (Homo sapiens)

Other forms of this molecule

p-Y599,Y605-EPHA1 [plasma membrane]

Inferred To

EPHA1 [plasma membrane] (Bos taurus)

EPHA1 [plasma membrane] (Caenorhabditis elegans)

EPHA1 [plasma membrane] (Canis familiaris)

EPHA1 [plasma membrane] (Danio rerio)

EPHA1 [plasma membrane] (Drosophila melanogaster)

EPHA1 [plasma membrane] (Gallus gallus)

EPHA1 [plasma membrane] (Mus musculus)

EPHA1 [plasma membrane] (Sus scrofa)

Epha1 [plasma membrane] (Rattus norvegicus)

Homologues of EPHA1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_005223.4

ZINC - World Drugs

EPHA1_HUMAN

Guide to Pharmacology - Targets

1821

OpenTargets

ENSG00000146904

ZINC - FDA approved

EPHA1_HUMAN

ZINC - Substances

EPHA1_HUMAN

ZINC - Biogenic

EPHA1_HUMAN

ZINC target

P21709

PRO

P21709

PDB

3KKA, 2K1L, 3HIL, 2K1K

ZINC - Investigational

EPHA1_HUMAN

IntEnz

2.7.10.1

GeneCards

P21709

HPA

ENSG00000146904-EPHA1

Ensembl

ENST00000275815, ENSP00000494931, ENSP00000275815, ENST00000645847, ENSG00000284816, ENSG00000146904

Pharos - Targets

P21709

ZINC - Predictions - Purchasable

EPHA1_HUMAN

HMDB Protein

HMDBP01345

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.519	2
IntAct:EBI-1108795 NPM			0.499	3
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.483	2