KIT C443S [plasma membrane]

Stable Identifier
R-HSA-9680038
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
KIT C443S [plasma membrane] icon
KIT C443S [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P10721 KIT
Gene Names
KIT, SCFR
Chain
signal peptide:1-25, chain:26-976
Reference Genes
BioGPS Gene:3815 KIT
COSMIC (genes):KIT KIT
CTD Gene:3815 KIT
dbSNP Gene:3815 KIT
ENSEMBL:ENSG00000157404 KIT
ENSEMBL_homo_sapiens_GENE:ENSG00000157404.17 KIT
HGNC:6342 KIT
KEGG Gene (Homo sapiens):3815 KIT
Monarch:3815 KIT
NCBI Gene:3815 KIT
OMIM:164920 KIT
UCSC:P10721 KIT
Reference Transcript
Other Identifiers
11721613_a_at
11721614_a_at
11746065_a_at
16966855
1888_s_at
205051_PM_s_at
205051_s_at
2727601
2727602
2727616
2727620
2727621
2727624
2727625
2727626
2727628
2727631
2727633
2727634
2727635
2727636
2727637
2727638
2727639
2727640
2727641
2727642
2727643
2727644
2727645
2727646
2727647
2727648
3815
8095110
A_14_P122291
A_14_P130973
A_14_P135100
A_23_P110253
A_33_P3303245
A_33_P3407034
GE59676
GO:0000166
GO:0001541
GO:0001650
GO:0001669
GO:0002020
GO:0002244
GO:0002318
GO:0002320
GO:0002327
GO:0002376
GO:0002551
GO:0002732
GO:0003012
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005020
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006687
GO:0006954
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007283
GO:0007286
GO:0008283
GO:0008284
GO:0008354
GO:0008360
GO:0008542
GO:0008584
GO:0009314
GO:0009897
GO:0009898
GO:0009986
GO:0010628
GO:0010863
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019827
GO:0019838
GO:0019955
GO:0022414
GO:0023052
GO:0030032
GO:0030036
GO:0030097
GO:0030154
GO:0030183
GO:0030217
GO:0030218
GO:0030318
GO:0030335
GO:0031274
GO:0031401
GO:0031410
GO:0032765
GO:0035019
GO:0035162
GO:0035234
GO:0035556
GO:0035701
GO:0035855
GO:0036211
GO:0038093
GO:0038109
GO:0038162
GO:0042127
GO:0042169
GO:0042531
GO:0042803
GO:0043069
GO:0043226
GO:0043235
GO:0043303
GO:0043410
GO:0043473
GO:0043586
GO:0045747
GO:0045937
GO:0046427
GO:0046686
GO:0046777
GO:0046872
GO:0048066
GO:0048170
GO:0048565
GO:0048584
GO:0048856
GO:0048863
GO:0048870
GO:0050673
GO:0050877
GO:0050910
GO:0051091
GO:0051093
GO:0051897
GO:0060089
GO:0060326
GO:0060374
GO:0070662
GO:0070668
GO:0097324
GO:0097326
GO:0120072
GO:0140096
GO:1901135
GO:1904251
GO:1904343
GO:1904349
GO:1905065
GO:2000242
HMNXSV003047477
HMNXSV003050311
ILMN_1790160
PH_hs_0004671
TC04000313.hg
X06182_s_at
g4557694_3p_a_at
Participates
as a component of
as a candidate of
Other forms of this molecule
KIT C443Y [plasma membrane]
KIT T417_D419delinsY [plasma membrane]
KIT S476I [plasma membrane]
KIT K509I [plasma membrane]
KIT D419A [plasma membrane]
KIT D419del [plasma membrane]
KIT S501_A502dup [plasma membrane]
KIT D419G [plasma membrane]
KIT N505_F508dup [plasma membrane]
KIT D419N [plasma membrane]
KIT S476N [plasma membrane]
KIT D419H [plasma membrane]
KIT V560_L576del [plasma membrane]
KIT Y823N [plasma membrane]
KIT Y823C [plasma membrane]
p6Y-KIT Y823D [plasma membrane]
p7Y-KIT D816V [plasma membrane]
p7Y-KIT K642E [plasma membrane]
p7Y-KIT N822K [plasma membrane]
p7Y-KIT N822D [plasma membrane]
p7Y-KIT N822S [plasma membrane]
p-7Y KIT V654E [plasma membrane]
p7Y-KIT N822I [plasma membrane]
p7Y-KIT D816N [plasma membrane]
p7Y-KIT A829P [plasma membrane]
p7Y-KIT D816H [plasma membrane]
p6Y-KIT Y823C [plasma membrane]
p7Y-KIT K642Q [plasma membrane]
p6Y-KIT Y823N [plasma membrane]
p7Y-KIT D816A [plasma membrane]
p7Y-KIT N822H [plasma membrane]
p7Y-KIT D816F [plasma membrane]
p-7Y KIT V654A [plasma membrane]
p7Y-KIT N822T [plasma membrane]
p7Y-KIT D816E [plasma membrane]
p7Y-KIT D816Y [plasma membrane]
p7Y-KIT N822Y [plasma membrane]
p7Y-KIT V559D [plasma membrane]
p-7Y-KIT K550I;P551_V555del [plasma membrane]
p-7Y KIT W557_K558del [plasma membrane]
p-5Y KIT V560_L576del [plasma membrane]
p7Y-KIT L576P [plasma membrane]
p7Y-KIT V559_V560del [plasma membrane]
p7Y-KIT P551_V555del [plasma membrane]
p7Y-KIT V560G [plasma membrane]
p7Y-KIT K550_K558del [plasma membrane]
p7Y-KIT V560E [plasma membrane]
p7Y-KIT V560D [plasma membrane]
p7Y-KIT V559A [plasma membrane]
p7Y-KIT V559I [plasma membrane]
p7Y-KIT W557R [plasma membrane]
p7Y-KIT V559G [plasma membrane]
p7Y-KIT W557G [plasma membrane]
p7Y-KIT K509I [plasma membrane]
p-7Y-KIT A502_Y503dup [plasma membrane]
p7Y-KIT S476I [plasma membrane]
p7Y-KIT C443Y [plasma membrane]
p7Y-KIT D419A [plasma membrane]
p-7Y-KIT T417_D419delinsY [plasma membrane]
p7Y-KIT D419H [plasma membrane]
p-7Y-KIT S501_A502dup [plasma membrane]
p7Y-KIT D419del [plasma membrane]
p-7Y-KIT N505_F508dup [plasma membrane]
p7Y-KIT D419N [plasma membrane]
p7Y-KIT C443S [plasma membrane]
p7Y-KIT S476N [plasma membrane]
p7Y-KIT D419G [plasma membrane]
KIT A829P [plasma membrane]
KIT N822D [plasma membrane]
KIT V654E [plasma membrane]
KIT W557R [plasma membrane]
KIT W557G [plasma membrane]
KIT V559A [plasma membrane]
KIT K550I;P551_V555del [plasma membrane]
KIT L576P [plasma membrane]
KIT V559_V560del [plasma membrane]
KIT P551_V555del [plasma membrane]
KIT V559I [plasma membrane]
KIT K550_K558del [plasma membrane]
KIT V559G [plasma membrane]
KIT V559D [plasma membrane]
KIT W557_K558del [plasma membrane]
KIT Y823D [plasma membrane]
KIT D816V [plasma membrane]
KIT N822Y [plasma membrane]
KIT T670I [plasma membrane]
KIT D820E [plasma membrane]
KIT V654A [plasma membrane]
KIT D816H [plasma membrane]
KIT K642E [plasma membrane]
KIT V560D [plasma membrane]
KIT N822H [plasma membrane]
KIT A502_Y503dup [plasma membrane]
KIT N822K [plasma membrane]
KIT D816Y [plasma membrane]
KIT D820A [plasma membrane]
KIT N822T [plasma membrane]
KIT D816F [plasma membrane]
KIT K642Q [plasma membrane]
KIT D816E [plasma membrane]
KIT N822I [plasma membrane]
KIT V560E [plasma membrane]
KIT N822S [plasma membrane]
KIT D816N [plasma membrane]
KIT D816A [plasma membrane]
KIT V560G [plasma membrane]
p-8Y-KIT [plasma membrane]
p-S741,S746-KIT [plasma membrane]
KIT [plasma membrane]
p-7Y-KIT [plasma membrane]
Modified Residues
Name
L-cysteine 443 replaced with L-serine
Coordinate
443
PsiMod
L-cysteine removal [MOD:01635]
A protein modification that effectively removes or replaces an L-cysteine.
L-serine residue [MOD:00025]
A protein modification that effectively converts a source amino acid residue to L-serine.
Disease
Name Identifier Synonyms
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
COSMIC
IntEnz
GeneCards
HPA
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P27986 PIK3R1  16 0.749 19
 UniProt:P62993 GRB2  1 0.743 6
 UniProt:P19174 PLCG1  6 0.675 31
 UniProt:O00459 PIK3R2  3 0.59 19
 UniProt:Q14451 GRB7  1 0.59 4
 UniProt:P46108 CRK  1 0.59 4
 UniProt:P21583 KITLG      0.544 2
 UniProt:P35235 Ptpn11  5 0.524 2
 UniProt:Q8VBX6 MPDZ      0.508 4
 ChEBI:39112 BOSUTINIB      0.499 2
 ChEBI:45783 IMATINIB      0.499 3
 ChEBI:49375 DASATINIB      0.499 2
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