Reactome | SSTR2 [plasma membrane]

SSTR2 [plasma membrane]

Stable Identifier

R-HSA-374757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Somatostatin receptor type 2, SSR2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30874 SSTR2

Gene Names

SSTR2

Chain

chain:1-369

Reference Genes

BioGPS Gene:6752 SSTR2

COSMIC (genes):SSTR2 SSTR2

CTD Gene:6752 SSTR2

dbSNP Gene:6752 SSTR2

ENSEMBL:ENSG00000180616 SSTR2

ENSEMBL_homo_sapiens_GENE:ENSG00000180616.9 SSTR2

HGNC:11331 SSTR2

KEGG Gene (Homo sapiens):6752 SSTR2

Monarch:6752 SSTR2

NCBI Gene:6752 SSTR2

OMIM:182452 SSTR2

UCSC:P30874 SSTR2

Reference Transcript

RefSeq:NM_001050.2 SSTR2

Other Identifiers

11739332_at

11739333_at

16837426

214597_3p_at

214597_PM_at

214597_at

217455_PM_s_at

217455_s_at

233310_3p_at

233310_PM_at

233310_at

239031_PM_at

239031_at

3733915

3733916

3733917

3733920

3733921

3733922

3733923

3733924

3733925

3733926

3733927

3733928

3733929

3733930

3733931

3733932

3733933

40919_at

54346_at

6752

8009526

84962_f_at

A_14_P133564

A_14_P136026

A_23_P318800

A_23_P38630

A_32_P6575

A_33_P3329013

A_33_P3352467

GE62630

GO:0003012

GO:0004930

GO:0004994

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007193

GO:0007218

GO:0007283

GO:0008285

GO:0016020

GO:0021549

GO:0022414

GO:0023052

GO:0030165

GO:0030432

GO:0030900

GO:0038170

GO:0042594

GO:0042923

GO:0043005

GO:0048856

GO:0060089

GO:0071385

GO:0071392

HMNXSV003012109

HMNXSV003027471

Hs.184841.0.S2_3p_x_at

Hs.184841.1.S1_3p_a_at

Hs.306358.0.S1_3p_at

Hs.306358.0.S1_3p_x_at

Hs.45177.0.A1_3p_at

ILMN_2152257

M81830_at

PH_hs_0026924

PH_hs_0029376

TC17000821.hg

TC17002346.hg

p7500

Participates

as a member of

Somatostatin receptors [plasma membrane] (Homo sapiens)

Inferred To

Sstr2 [plasma membrane] (Mus musculus)

Sstr2 [plasma membrane] (Rattus norvegicus)

SS2R [plasma membrane] (Gallus gallus)

SSTR2 [plasma membrane] (Bos taurus)

SSTR2 [plasma membrane] (Canis familiaris)

SSTR2 [plasma membrane] (Sus scrofa)

sstr2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001041.1

Guide to Pharmacology - Targets

356

OpenTargets

ENSG00000180616

ZINC - Substances

SSR2_HUMAN

ZINC target

P30874

PRO

P30874

PDB

7XAT, 7XMR, 7WIG, 7T10, 7Y27, 7YAC, 7UL5, 7WJ5, 7WIC, 7Y26, 7XAV, 7Y24, 7T11, 7XAU, 7YAE

ZINC - Investigational

SSR2_HUMAN

GeneCards

P30874

HPA

ENSG00000180616-SSTR2

Ensembl

ENSG00000180616, ENSP00000350198, ENST00000357585

Pharos - Targets

P30874

ZINC - Predictions - Purchasable

SSR2_HUMAN

HMDB Protein

HMDBP08008

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.639	5